Cycloparaphenylenes via [2+2+2] cycloaddition.
Cycloparaphenylenes via [2+2+2] cycloaddition.
复制标题
通过[2 2 2]环加成形成环对亚苯基。
DOI：
10.1039/d2cc02289c
复制
发表时间：
2022
影响因子：
4.9
通讯作者：
Hermann A. Wegner
中科院分区：
文献类型：
--
作者：
Daniel Kohrs;Jannis Volkmann;Hermann A. Wegner
[2+2+2]环加成反应（CA）作为一种原子经济的合成取代芳环的方法，具有很大的潜力。在这篇文章中，我们强调了这种多功能的方法对取代的环对苯（CPPs）的合成方法中的应用。[2+2+2] CA可以根据目标CPP接管合成中的不同任务。这些方法分为三个关键步骤：芳构化（最终完成CPP），大环化（形成应变减少的大环）和[2+2+2] CA。基于这种分析，根据[2+2+2] CA完成的任务，将策略分为四类。我们指出了每种合成策略的优点和缺点，并总结了我们的研究结果，以使读者能够轻松地了解这一研究领域。
The [2+2+2] cycloaddition (CA) offers great potential as an atom economic method for the formation of substituted aromatic rings. In this article, we highlight the application of this versatile method in synthetic approaches towards substituted cycloparaphenylenes (CPPs). The [2+2+2] CA can take over different tasks within the synthesis depending on the targeted CPP. These approaches were divided into three key steps: aromatization (which finalises the CPP), macrocyclization (the formation of a strain-reduced macrocycle) and the [2+2+2] CA. Based on this analysis the strategies were categorised into four classes based on which task the [2+2+2] CA fulfills. We point out the benefits and drawbacks of each synthesic strategy and summarize our findings to provide the reader with an easy insight into this research field.