Body mass index and leukocyte telomere length in adults: a systematic review and meta-analysis
Body mass index and leukocyte telomere length in adults: a systematic review and meta-analysis
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DOI：
10.1111/obr.12126
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发表时间：
2014-03-01
期刊：
影响因子：
8.9
通讯作者：
Brenner, H.
中科院分区：
文献类型：
--
作者：
Mueezzinler, A.;Zaineddin, A. K.;Brenner, H.
本研究的目的是对身体质量指数（BMI）与白细胞端粒长度（LTL）之间关系的研究进行系统回顾和荟萃分析。通过系统检索MEDLINE、Embase和Web of Knowledge数据库确定相关研究。采用荟萃分析方法计算了横断面和纵向研究的综合相关系数和回归系数。没有合适数据进行荟萃分析的研究分别汇总。总共纳入了29项研究，其中16项符合荟萃分析的条件，包括两项纵向研究。大多数研究报告BMI和端粒长度呈反比关系。在横断面研究中，相关系数和回归系数的汇总估计值分别为-0.057（95%可信区间[CI]: -0.102至-0.012）和-0.008 kBP kg m(-2) （95% CI: -0.016至0.000）。这两项纵向研究规模较小（70人和311人），涵盖不同的年龄范围，得出的结果不一致。没有观察到任何性别差异的证据。尽管研究之间存在差异，且纵向研究的数据非常有限，但本荟萃分析的结果表明，成人BMI和LTL之间存在生物学上合理的负相关。然而，这些关联需要澄清，特别是通过大型纵向研究，仔细控制总体、年龄和性别特定分析中可能的混杂因素。
The objective of this study was to provide a systematic review and meta-analysis of studies on the relationship between body mass index (BMI) and leukocyte telomere length (LTL). Relevant studies were identified by a systematic search of MEDLINE, Embase and Web of Knowledge databases. Pooled correlation and regression coefficients were calculated using meta-analysis methods for both cross-sectional and longitudinal studies. Studies without suitable data for meta-analysis were summarized separately. Overall, 29 studies were included, of which 16 were eligible for meta-analysis, including two longitudinal studies. The majority of studies reported an inverse relationship between BMI and telomere length. For cross-sectional studies, the pooled estimates for correlation and regression coefficients were -0.057 (95% confidence interval [CI]: -0.102 to -0.012) and -0.008 kBP kg m(-2) (95% CI: -0.016 to 0.000), respectively. The two longitudinal studies were small (70 and 311 subjects), covered different age ranges and yielded inconsistent results. No evidence of any gender difference was observed. Despite some variation between studies and very limited data from longitudinal studies, the results of this meta-analysis suggest a biologically plausible inverse association between BMI and LTL in adults. However, the associations require clarification, in particular by large longitudinal studies with careful control for possible confounding factors in overall, age- and sex-specific analyses.