Electroacupuncture accelerates gastric emptying in association with changes in vagal activity
Electroacupuncture accelerates gastric emptying in association with changes in vagal activity
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DOI：
10.1152/ajpgi.00272.2001
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发表时间：
2002-02-01
影响因子：
4.5
通讯作者：
Chen, JDZ
中科院分区：
文献类型：
--
作者：
Ouyang, H;Yin, JY;Chen, JDZ
胃轻瘫是一种缺乏治疗选择的疾病，本研究探讨了电针对胃排空的影响及其机制。植入十二指肠插管和浆膜电极的狗喂食混合酚红的Ensure，并收集胃流出液。电针于餐前30分钟至餐后45分钟进行。记录胃肌电活动和心电图。电针可显著改善胃排空。通过心率变异性谱分析评估的迷走神经活动在电针治疗后明显增加。电针增加了胃近端和远端慢波的规律性。它还增加了远端胃而不是近端胃的尖峰爆发次数。电针加速狗胃排空液体及其治疗胃轻瘫的潜力可以探索。这种作用可能是由于胃慢波节律性和胃窦收缩（尖峰）活动的改善，可能涉及迷走神经通路。
Gastroparesis is a disorder with a lack of treatment options and this study investigated the effect of electroacupuncture on gastric emptying and involved mechanisms. Dogs implanted with a duodenal cannula and serosal electrodes were fed with Ensure mixed with phenol red, and the gastric effluent was collected. Electroacupuncture was performed from 30 min before until 45 min after the meal. Gastric myoelectrical activity and electrocardiogram were recorded. Gastric emptying was significantly improved with electroacupuncture. Vagal activity assessed from the spectral analysis of heart rate variability was markedly increased with electroacupuncture. Electroacupuncture increased the regularity of gastric slow waves in both the proximal and distal stomach. It also increased the number of spike bursts in the distal but not proximal stomach. Electroacupuncture accelerates gastric emptying of liquid in dogs and its potential for treating gastroparesis may be explored. The effect may be attributed to improvement in gastric slow-wave rhythmicity and antral contractile (spike) activity and may possibly involve the vagal pathway.