Modulation of neurophysiological auditory processing measures by bilateral transcranial direct current stimulation in schizophrenia
Modulation of neurophysiological auditory processing measures by bilateral transcranial direct current stimulation in schizophrenia
复制标题
DOI：
10.1016/j.schres.2016.04.021
复制
发表时间：
2016-07-01
影响因子：
4.5
通讯作者：
Green, Michael F.
中科院分区：
文献类型：
--
作者：
Dunn, Walter;Rassovsky, Yuri;Green, Michael F.
本研究采用双侧经颅直流电刺激(TDC)，靶向产生精神分裂症患者听觉失配负波(MMN)和奇怪的P300。TDC应用于前额叶皮质，采用平行组间设计。刺激对MMN波幅的调制有显著的主效应。这种效应主要是由阳极刺激引起的MMN波幅的不显著但较大的效应大小降低所驱动的。这是第一项证明tDCs能够参与和调节精神分裂症患者基于脑电的听觉处理措施的研究。爱思唯尔出版公司(Elsevier B.V.)
This study used bilateral transcranial direct current stimulation (tDCS) to target neural generators of auditory Mismatch Negativity (MMN) and oddball P300 in schizophrenia patients. tDCS was applied to the pre-frontal cortex in a parallel between-group design. There was a significant main effect of stimulation resulting in modulation of MMN amplitude. This effect was mainly driven by a non-significant, but large, effect-size decrease in MMN amplitude with anodal stimulation. This is the first study to demonstrate that tDCS is able to engage and modulate an EEG-based auditory processing measure in schizophrenia. Published by Elsevier B.V.