BTN3A2 serves as a prognostic marker and favors immune infiltration in triple-negative breast cancer
BTN3A2 serves as a prognostic marker and favors immune infiltration in triple-negative breast cancer
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DOI：
10.1002/jcb.29485
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发表时间：
2019-11-06
影响因子：
4
通讯作者：
Zhao, Jinmin
中科院分区：
文献类型：
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作者：
Cai, Peian;Lu, Zhenhui;Zhao, Jinmin
据报道，免疫浸润与肿瘤的进展密切相关。鉴于BTN3A2是免疫激活的重要介质，本研究旨在通过广泛的肿瘤分析，探讨BTN3A2在免疫侵袭和肿瘤预后中的作用。用Oncomine和Timer数据库分析BTN3A2在广泛性肿瘤中的表达水平。单因素和多因素COX回归分析评估BTN3A2与各种肿瘤预后的关系。用TIMER数据库评价BTN3A2与免疫渗透的相关性。提示BTN3A2是乳腺癌(BRCA)和卵巢癌(OV)的潜在预后指标。然而，与OV和BRCA的其他亚型相比，三阴性乳腺癌(TNBC)的免疫浸润与BTN3A2高度相关。多因素Cox回归分析显示BTN3A2是TNBC的独立预后标志，加权相关网络分析显示BTN3A2仅与TNBC相关，与BRCA的其他亚型无关。免疫细胞亚型相关分析显示，BTN3A2与TNBC中的普通T细胞、CD8+T细胞、辅助性T细胞1型、耗竭T细胞、树突状细胞高度相关。BTN3A2的共表达基因集主要参与T细胞受体相互作用和核因子-kappaB信号通路。总之，BTN3A2可通过调节T细胞受体相互作用和核因子-kappaB信号通路，作为诊断和独立预测TNBC预后的特异性标志物。
Immune infiltration is reported to be highly associated with tumor progress. Since butyrophilin subfamily 3 member A2 (BTN3A2) serves as a crucial mediator in immune activation, we aimed to investigate the correlation of BTN3A2 in immune infiltration and tumor prognosis via extensive-cancer analysis. The levels of BTN3A2 expression in extensive cancers were analyzed with Oncomine and TIMER databases. Univariate cox and multivariate cox regression analyses were conducted to assess the associations of BTN3A2 to prognosis of various cancers. The correlations of BTN3A2 with immune infiltration were assessed by TIMER database. It suggested that BTN3A2 was a potential prognosis signature for breast cancer (BRCA) and ovarian cancer (OV). However, immune infiltrations were highly correlated with BTN3A2 in triple-negative breast cancer (TNBC), compared with OV and other subtypes of BRCA. Multivariate cox regression analysis revealed that BTN3A2 was an independently prognostic signature of TNBC, as well as weighted correlation network analysis suggested BTN3A2 was only correlated with TNBC, rather than other subtypes of BRCA. Immune cell subtypes correlation analysis showed that BTN3A2 was highly correlated with general T, CD8+ T, T helper type 1, exhausted T cells, and dendritic cells in TNBC. And the coexpression geneset of BTN3A2 was mainly involved in T-cell receptor interaction and the nuclear factor-kappa B (NF-kappa B) signaling pathway. Collectively, BTN3A2 that was positively associated with better prognosis could be served as a special diagnostic and independently prognostic marker for TNBC by regulating the T-cell receptor interaction and NF-kappa B signaling pathways.