Systemic inflammation is an independent predictive marker of clinical outcomes in mucosal squamous cell carcinoma of the head and neck in oropharyngeal and non-oropharyngeal patients.
Systemic inflammation is an independent predictive marker of clinical outcomes in mucosal squamous cell carcinoma of the head and neck in oropharyngeal and non-oropharyngeal patients.
复制标题
全身性炎症是口咽和非咽咽患者粘膜鳞状细胞癌的临床结果的独立预测标记。
DOI：
10.1186/s12885-016-2089-4
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发表时间：
2016-02-18
期刊：
影响因子：
3.8
通讯作者：
Eade T
中科院分区：
文献类型：
--
作者：
Charles KA;Harris BD;Haddad CR;Clarke SJ;Guminski A;Stevens M;Dodds T;Gill AJ;Back M;Veivers D;Eade T
目前，很少有生物标志物来识别头颈部鳞状细胞癌（HNSCC）癌症患者，其复发风险更大，生存期缩短。本研究旨在研究系统性炎症标志物嗜中性粒细胞与淋巴细胞比率（NLR）是否可预测异质性HNSCC癌症患者队列的临床结局。我们进行了一项回顾性分析，以确定NLR和临床病理特征与无复发生存期（RFS）和总生存期（OS）之间的关系。单变量分析用于确定相关性，选择的变量包括在多变量考克斯回归分析中以确定预测值。共分析了145例接受过放疗的I-IV期HNSCC患者。这些患者中有76例患有口咽癌，69例患有非口咽HNSCC，这些人群分别进行了分析。NLR与任何临床病理变量无关。在单变量分析中，两个亚群的NLR均与RFS和OS相关。多变量分析显示，NLR > 5的患者在两个亚群中都缩短了OS，但NLR > 5仅预测口咽部患者的RFS。在两个亚群中，体能状态差预测的OS和当前吸烟者缩短了非口咽部患者的OS和RFS。结果显示，NLR > 5的患者预测总生存期较短。需要在更大的队列中进行进一步的前瞻性验证研究，以确定NLR在HNSCC患者中的临床适用性。本文的在线版本（doi：10.1186/s12885-016-2089-4）包含补充材料，可供授权用户使用。
Currently there are very few biomarkers to identify head and neck squamous cell carcinoma (HNSCC) cancer patients at a greater risk of recurrence and shortened survival. This study aimed to investigate whether a marker of systemic inflammation, the neutrophil-to-lymphocyte ratio (NLR), was predictive of clinical outcomes in a heterogeneous cohort of HNSCC cancer patients. We performed a retrospective analysis to identify associations between NLR and clinicopathological features to recurrence free survival (RFS) and overall survival (OS). Univariate analysis was used to identify associations and selected variables were included in multivariable Cox regression analysis to determine predictive value. A total of 145 patients with stage I-IV HNSCC that had undergone radiotherapy were analysed. Seventy-six of these patients had oropharyngeal cancer and 69 had non-oropharyngeal HNSCC and these populations were analysed separately. NLR was not associated to any clinicopathological variable. On univariate analysis, NLR showed associations with RFS and OS in both sub-populations. Multivariable analysis showed patients with NLR > 5 had shortened OS in both sub-populations but NLR > 5 only predicted RFS in oropharyngeal patients. Poor performance status predicted OS in both sub-populations and current smokers had shortened OS and RFS in non-oropharyngeal patients. The results show patients with NLR > 5 predict for shorter overall survival. Further prospective validation studies in larger cohorts are required to determine the clinical applicability of NLR for prognostication in HNSCC patients. The online version of this article (doi:10.1186/s12885-016-2089-4) contains supplementary material, which is available to authorized users.