ACQUISITION OF CONDITIONED TASTE-AVERSION IN RATS IS MEDIATED BY IPSILATERAL INTERACTION OF CORTICAL AND MESENCEPHALIC MECHANISMS
ACQUISITION OF CONDITIONED TASTE-AVERSION IN RATS IS MEDIATED BY IPSILATERAL INTERACTION OF CORTICAL AND MESENCEPHALIC MECHANISMS
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DOI：
10.1016/0304-3940(91)90566-c
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发表时间：
1991-12-09
影响因子：
2.5
通讯作者：
BURES, J
中科院分区：
文献类型：
--
作者：
GALLO, M;BURES, J
用功能性半去皮质和单侧臂旁核注射河豚毒素（TTX）的方法，研究了介导条件性味觉厌恶（CTA）的神经回路偏侧化的可能性。大鼠在右半球皮层扩散性抑制（CSD）期间饮用糖精（CS），在腹腔注射氯化锂（LiCl）（US）之前不久接受单侧PBN注射TTX（3 ng），当CSD和TTX施加于同一半球时形成CTA，而当施加于不同半球时则不形成CTA。大鼠饮用糖精与完整的大脑，并接受单方面TTX重叠与氯化锂管理学会了一个弱CTA，检索中断同侧或对侧CSD在保留测试。可以得出结论，CTA采集需要同侧皮质和皮质下中心的合作，但单侧皮质下CTA印迹的形成并不保证检索过程的偏侧化。
The possibility to lateralize the neural circuits mediating conditioned taste aversion (CTA) has been examined by combination of functional hemidecortication and unilateral tetrodotoxin (TTX) injection into the parabrachial nucleus (PBN). Rats drinking saccharin (CS) during cortical spreading depression (CSD) in the right hemisphere and receiving unilateral PBN injection of TTX (3 ng) shortly before i.p. injection of lithium chloride (LiCl) (US) formed CTA when CSD and TTX were applied to the same hemisphere but not when applied to different hemispheres. Rats drinking saccharin with intact brain and receiving unilateral TTX overlapping with LiCl administration learned a weak CTA, the retrieval of which was disrupted by either ipsilateral or contralateral CSD during retention testing. It is concluded that CTA acquisition requires cooperation of ipsilateral cortical and subcortical centers but that formation of unilateral subcortical CTA engram does not warrant lateralization of the retrieval process.