The Evaluation of D-Dimer Levels for the Comparison of Fibrinogen and Fibrin Units Using Different D-Dimer Kits to Diagnose VTE
The Evaluation of D-Dimer Levels for the Comparison of Fibrinogen and Fibrin Units Using Different D-Dimer Kits to Diagnose VTE
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DOI：
10.1177/1076029617706755
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发表时间：
2018-05-01
影响因子：
2.9
通讯作者：
Sudo, Akihiro
中科院分区：
文献类型：
--
作者：
Hasegawa, Masahiro;Wada, Hideo;Sudo, Akihiro
对术前患者评估 D-二聚体水平诊断或预测深静脉血栓 (DVT) 发生的临界值，并与非 DVT 患者进行比较。术前采用乳胶凝集法或酶联免疫分析法测定 262 名骨科手术患者的 8 种不同 D-二聚体水平，以诊断亚临床 DVT 或预测术后 DVT。有 15 名患者出现亚临床 DVT，47 名患者出现术后 DVT，但 200 名患者根本没有 DVT。亚临床或术后 DVT 患者的所有 8 种血浆 D-二聚体值均显着高于无 DVT 患者或健康志愿者。对低 D-二聚体水平高度敏感的测定与 D-二聚体的野生范围测定之间的截止值存在差异。因此，对于诊断低水平的 D-二聚体，某些 D-二聚体检测可能比其他检测更有用。尽管 D-二聚体水平的测量对于诊断亚临床 DVT 和预测 DVT 风险很有用，但诊断或预测 DVT 的临界值各不相同。预测术后 DVT 的截止值为 1.7 μg/mL（D-二聚体 A-D）和 1.0 μg/mL（D-二聚体 E-H）。
The cutoff values of D-dimer levels for diagnosing or predicting the occurrence of deep vein thrombosis (DVT) were evaluated in preoperative patients and compared to those in non-DVT patients. The levels of 8 different D-dimers were measured using the latex agglutination method or enzyme immunoassay before surgery in 262 orthopedic surgery patients to diagnose subclinical DVT or predict postoperative DVT. There were 15 patients with subclinical DVT and 47 with postoperative DVT, but 200 patients had no DVT at all. All 8 plasma D-dimer values were significantly higher in the patients with subclinical or postoperative DVT than in those without DVT or in healthy volunteers. There were differences in the cutoff values between the assays highly sensitive for low D-dimer levels and wild-range assays of D-dimers. Some D-dimer assays might therefore be more useful than others for diagnosing low levels of D-dimer. Although the measurement of D-dimer levels was useful for diagnosing subclinical DVT and predicting the risk of DVT, the cutoff values for the diagnosis or prediction of DVT varied. The cutoff values for the prediction of postoperative DVT were 1.7 mu g/mL (D-dimer A-D) and 1.0 mu g/mL (D-dimer E-H).