Neuronal gene expression correlates of Parkinson's disease with dementia.
Neuronal gene expression correlates of Parkinson's disease with dementia.
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DOI：
10.1002/mds.22184
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发表时间：
2008-08-15
影响因子：
8.6
通讯作者：
Dunckley, Travis
中科院分区：
文献类型：
--
作者：
Stamper, Chelsea;Siegel, Andrew;Liang, Winnie S.;Pearson, John V.;Stephan, Dietrich A.;Shill, Holly;Connor, Don;Caviness, John N.;Sabbagh, Marwan;Beach, Thomas G.;Adler, Charles H.;Dunckley, Travis
痴呆症是帕金森氏病(PD)患者常见的致残并发症。帕金森氏病合并痴呆症(PDD)的潜在分子病因尚不清楚。为了确定与PDD相关的候选基因和分子通路，我们对易感皮质神经元群体进行了全基因组表达谱分析。结果显示，认知正常的帕金森病患者(PD-CogNL)和正常对照组的162个基因的表达有显著差异(P<；0.01)。相比之下，与健康对照组或PD-CogNL患者相比，PDD患者中有556个基因(P<；0.01)显著改变。这些结果与PDD相对于PD-CogNL的皮质病理增加是一致的，并确定了与PDD病理增加相关的潜在分子变化。最后，我们在PD皮质神经元中发现了69个基因的表达差异，这些基因发生在痴呆发病前，并在痴呆发生时加剧，提示它们可能是PD痴呆发病的相关症状前因素。这些结果为与PDD相关的皮质分子变化提供了新的见解，并为对PDD感兴趣的研究人员提供了一个非常有用的参考数据库。
Dementia is a common disabling complication in patients with Parkinson's disease (PD). The underlying molecular causes of Parkinson's disease with dementia (PDD) are poorly understood. To identify candidate genes and molecular pathways involved in PDD, we have performed whole genome expression profiling of susceptible cortical neuronal populations. Results show significant differences in expression of 162 genes (P < 0.01) between PD patients who are cognitively normal (PD-CogNL) and controls. In contrast, there were 556 genes (P < 0.01) significantly altered in PDD compared to either healthy controls or to PD-CogNL cases. These results are consistent with increased cortical pathology in PDD relative to PD-CogNL and identify underlying molecular changes associated with the increased pathology of PDD. Lastly, we have identified expression differences in 69 genes in PD cortical neurons that occur before the onset of dementia and that are exacerbated upon the development of dementia, suggesting that they may be relevant presymptomatic contributors to the onset of dementia in PD. These results provide new insights into the cortical molecular changes associated with PDD and provide a highly useful reference database for researchers interested in PDD.
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影响因子：
56.9
作者：
Singleton, AB;Farrer, M;Gwinn-Hardy, K
通讯作者：
Gwinn-Hardy, K
影响因子：
6.1
作者：
Cantuti-Castelvetri, Ippolita;Keller-McGandy, Christine;Standaert, David G.
通讯作者：
Standaert, David G.
影响因子：
2.2
作者：
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通讯作者：
Zhao, Y
影响因子：
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作者：
Ostrerova-Golts, N;Petrucelli, L;Wolozin, B
通讯作者：
Wolozin, B
影响因子：
9.9
作者：
Kraybill, ML;Larson, EB;Cherrier, MM
通讯作者：
Cherrier, MM