Acute and chronic hyperosmolality. Effects on cerebral amino acids and energy metabolism.
Acute and chronic hyperosmolality. Effects on cerebral amino acids and energy metabolism.
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急性和慢性高渗透压。
DOI：
10.1001/archneur.1975.00490430084018
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发表时间：
1975
影响因子：
--
通讯作者：
A. Lockwood
中科院分区：
文献类型：
--
作者：
A. Lockwood
在大鼠和小鼠中诱导了急性和慢性渗透压升高。在高渗透压48至96小时后，大鼠脑内谷氨酰胺浓度上升至对照组的210%之间。这一增加可能占到了先前假设的使大脑能够抵抗体积变化的自发性渗透膜的20%。急性和慢性高渗小鼠的大脑代谢率降低，尽管三磷酸腺苷和磷酸肌酸水平正常。
Acute and chronic elevations in osmolality were induced in rats and mice. After 48 and 96 hours of hyperosmolality, rat brain glutamine concentration increased to between 210% of control. This increase may account for 20% of the previously postulated idiogenic osmols that enable the brain to resist volume changes. Cerebral metabolic rates were reduced in the brains of mice made acutely and chronically hyperosmotic in spite of normal levels of adenosine triphosphate and phosphocreatine.