Longitudinal screening for prostate cancer with prostate-specific antigen
Longitudinal screening for prostate cancer with prostate-specific antigen
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DOI：
10.1001/jama.276.16.1309
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发表时间：
1996-10-23
影响因子：
120.7
通讯作者：
Herschman, JD
中科院分区：
文献类型：
--
作者：
Smith, DS;Catalona, WJ;Herschman, JD
目的.-确定前 4 年基于前列腺特异性抗原 (PSA) 的系列筛查的依从性趋势、异常筛查测试结果的发生率、癌症检出率以及检测到的癌症的分期和分级。设计.-通过血清 PSA 测量进行前列腺癌系列筛查的社区研究。设置.-大学医疗中心。受试者.-总共 10 248 名年龄至少 50 岁的男性志愿者，每 6 个月进行一次筛查，至少 48 名主要结果指标：返回进行系列筛查的男性比例、PSA 水平升高的比例、PSA 水平新升高的比例、前列腺癌检出率以及诊断时肿瘤分期和分级的分布。结果：48 个月时，79% 的志愿者返回进行筛查。在此期间，血清 PSA 水平高于 4.0 ng/mL 的志愿者比例有所下降（从 10% 降至 6%-7%），癌症检出率（从 3% 降至
Objective.-To determine for the first 4 years of serial prostate-specific antigen (PSA)-based screening trends in compliance, prevalence of abnormal screening test results, cancer detection rates, and stage and grade of cancers detected.Design.-A community-based study of serial screening for prostate cancer with serum PSA measurements.Setting.-University medical center.Subjects.-A total of 10 248 male volunteers at least 50 years old who were screened at 6-month intervals for a minimum of 48 months.Main Outcome Measures.-The proportion of men who returned for serial screening, the proportion with elevated PSA levels, the proportion with newly elevated PSA levels, prostate cancer detection rates, and the distribution of tumor stages and grades at diagnosis.Results.-At 48 months, 79% of volunteers returned for screening. During this interval there was a decrease in the proportion of volunteers with serum PSA levels higher than 4.0 ng/mL (from 10% to 6%-7%), in cancer detection rates (from 3% to