Tactile imaging of an imbedded palpable structure for breast cancer screening.
Tactile imaging of an imbedded palpable structure for breast cancer screening.
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DOI：
10.1021/am5046789
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发表时间：
2014-09-24
影响因子：
9.5
通讯作者：
Saraf', Ravi F.
中科院分区：
文献类型：
--
作者：
Chieu Van Nguyen;Saraf', Ravi F.
除了纹理，人的手指还能感觉到触诊。嵌入结构的检测是基体、物体和装置的相对刚度之间的精细平衡。如果设备太软，其高响应性将限制嵌入结构可以被检测到的深度。触诊是医生检查异常的一种有效方法。在临床乳房检查（CBE）中，通过在70-90 kPa范围内的接触压力下按压超过1 cm 2的面积，医生感觉到比周围组织硬8- 18倍的癌性肿块。在5-10 mm范围内的肿块的早期检测导致良好的预后。我们描述了一种薄膜触觉装置，该装置模拟人类触摸来量化CBE，其通过使用1080 kPa压力在乳房模型中20 mm深度处对5-10 mm物体的大小和形状进行成像。设备的线性响应允许量化，其中灰度对应于相对局部刚度。来自小于2 mm的尺寸的<2.5倍硬度的物体的（背景）信号是最小的。
Apart from texture, the human finger can sense palpation. The detection of an imbedded structure is a fine balance between the relative stiffness of the matrix, the object, and the device. If the device is too soft, its high responsiveness will limit the depth to which the imbedded structure can be detected. The sensation of palpation is an effective procedure for a physician to examine irregularities. In a clinical breast examination (CBE), by pressing over 1 cm2 area, at a contact pressure in the 70–90 kPa range, the physician feels cancerous lumps that are 8- to 18-fold stiffer than surrounding tissue. Early detection of a lump in the 5–10 mm range leads to an excellent prognosis. We describe a thin-film tactile device that emulates human touch to quantify CBE by imaging the size and shape of 5–10 mm objects at 20 mm depth in a breast model using ∼80 kPa pressure. The linear response of the device allows quantification where the greyscale corresponds to the relative local stiffness. The (background) signal from <2.5-fold stiffer objects at a size below 2 mm is minimal.
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