Mast cell hyperplasia in the skin of Dsg4-deficient hypotrichosis mice, which are long-living mutants of lupus-prone mice
Mast cell hyperplasia in the skin of Dsg4-deficient hypotrichosis mice, which are long-living mutants of lupus-prone mice
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DOI：
10.1007/s00251-008-0320-4
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发表时间：
2008-08
期刊：
影响因子：
3.2
通讯作者：
Ming-Cai Zhang;H. Furukawa;K. Tokunaka;K. Saiga;F. Date;Y. Owada;M. Nose;M. Ono
中科院分区：
文献类型：
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作者：
Ming-Cai Zhang;H. Furukawa;K. Tokunaka;K. Saiga;F. Date;Y. Owada;M. Nose;M. Ono
桥粒钙粘蛋白是表皮中表达的重要细胞粘附分子。我们发现了一个突变的钙粘蛋白超家族成员，即桥粒芯糖蛋白4（Dsg 4），在早发性死亡（EOD）hagemice与hypothesia。该突变是通过将早期转座子II-β插入Dsg 4的内含子8中而诱导的。EODhagemice皮肤肥大细胞增生。异常扩增的flprT细胞群，即，EOD小鼠脾细胞中的CD 4 − CD 8 −B220+Thy1.2+αβT细胞在EODhagemice中减少。因此，怀疑长寿突变型EODhagemice是从狼疮倾向EOD小鼠中选择的，因为它们的免疫不成熟。这些发现清楚地表明Dsg 4是毛囊形成的重要分子，并假设由于Dsg 4突变，生长期的无组织增生毛囊为皮肤中的肥大细胞前体提供了小生境。
Desmosomal cadherins are essential cell adhesion molecules expressed in the epidermis. We identified a mutation of a cadherin superfamily member, namely, desmoglein 4 (Dsg4), in early onset of death (EOD)hagemice with hypotrichosis. The mutation was induced by the insertion of an early transposon II-β into intron 8 ofDsg4. Mast cell hyperplasia was observed in the skin of EODhagemice. The abnormally expanded population oflprT cells, i.e., CD4−CD8−B220+Thy1.2+αβT cells, in the splenocytes of EOD mice was reduced in EODhagemice. Therefore, it was suspected that the long-living mutant EODhagemice were selected from lupus-prone EOD mice because of their immunological immaturity. These findings clearly indicate thatDsg4is an important molecule for the formation of hair follicles and hypothesize that unorganized hyperplastic hair follicles in anagen due to theDsg4mutation provide niches for mast cell precursors in the skin.