Survivorship in a population based cohort of patients with Sjögren's syndrome, 1976-1992.
Survivorship in a population based cohort of patients with Sjögren's syndrome, 1976-1992.
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发表时间：
1999-06
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通讯作者：
P. B. Martens;S. Pillemer;L. Jacobsson;W. O'Fallon;E. Matteson
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作者：
P. B. Martens;S. Pillemer;L. Jacobsson;W. O'Fallon;E. Matteson
目的 干燥综合征 (SS) 与淋巴恶性肿瘤和其他重大医学并发症的发生有关，但在基于人群的样本中尚未报道 SS 对生存的影响。我们分析了 1976 年至 1992 年间美国明尼苏达州奥姆斯特德县居民中诊断为 SS 的患者的生存情况。方法回顾了医生诊断为 SS 的所有记录，以及诊断为口干症和干燥性角结膜炎的患者的所有记录，以及类风湿性关节炎 (RA) 和系统性红斑狼疮患者的记录。 SS 的病例定义需要 3 个标准中的 2 个：干燥性角结膜炎、口干症或血清学异常。排除了混杂疾病。所有患者都是白人。结果 在确定的 74 例 SS 病例中，50 例 (67%) 为原发性 SS，24 例 (33%) 为继发性 SS。原发性 SS 患者的平均随访时间为 7.2 年，继发性 SS 患者的平均随访时间为 9.9 年。与一般人群相比，SS 患者的死亡率增加 (p = 0.04)。当分别研究原发性和继发性 SS 患者时，发现继发性 SS 患者的死亡率增加 (p < 0.005)，但原发性 SS 患者的死亡率没有增加 (p = 0.86)。结论 在这个基于人群的队列中，原发性 SS 患者的死亡率并未增加。然而，继发性 SS 患者的死亡率可能会增加，其中大多数患有 RA。
OBJECTIVE Sjögren's syndrome (SS) has been associated with development of lymphoid malignancies and other significant medical complications, but the effect of SS on survival in a population based sample has not been reported. We analyzed survival in an incidence cohort of patients diagnosed with SS in residents of Olmsted County, Minnesota, USA, between 1976 and 1992. METHODS All records of physician diagnosed SS were reviewed, as well as all records from patients diagnosed with xerostomia and keratoconjunctivitis sicca, and records of patients with rheumatoid arthritis (RA) and systemic lupus erythematosus. The case definition for SS required 2 of 3 criteria: keratoconjunctivitis sicca, xerostomia, or serologic abnormality. Confounding illnesses were excluded. All patients were white. RESULTS Of the 74 cases of SS identified, 50 (67%) had primary SS and 24 (33%) secondary SS. An average of 7.2 years of followup was available for patients with primary SS and 9.9 years for patients with secondary SS. Compared with the general population, patients with SS had increased mortality (p = 0.04). When patients with primary and secondary SS were studied separately, increased mortality was found in patients with secondary SS (p < 0.005) but not primary SS (p = 0.86). CONCLUSION In this population based cohort, patients with primary SS did not have increased mortality. However, mortality may have been increased in patients with secondary SS, the majority of whom had RA.