Japanese Encephalitis Vaccines.
Japanese Encephalitis Vaccines.
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DOI：
10.1007/s40506-020-00242-5
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发表时间：
2020
影响因子：
2
通讯作者：
Satchidanandam V
中科院分区：
文献类型：
--
作者：
Satchidanandam V
作为一种明显的疫苗可预防疾病，由日本脑炎病毒（JEV）引起的脑炎引起了寻求开发病毒疫苗的人们的高度关注。自20世纪50年代以来，所有类型的JEV疫苗，包括灭活疫苗、重组疫苗和减毒活疫苗都已获得许可。作为一个极其成功的努力的例子，审查JEV疫苗的发展并探讨其一致成功背后的原因的时机已经成熟。从20世纪50年代中期小鼠脑生长灭活病毒制剂的首次许可到今天的减毒活病毒疫苗，针对JEV的疫苗已经走过了漫长的道路。针对JEV开发的各种灭活疫苗和活疫苗的调查提供了对所有可用于预防JEV脑炎的疫苗的令人印象深刻的安全性和有效性的惊人见解。这篇综述并列的研究，以了解自然获得的免疫力，对JEV，大多是在2000年后发表的，比较这些与疫苗引起的，并强调了缺乏的数据引起的细胞介导的免疫反应JEV疫苗。这篇文章不仅试图在一个集合中提供关于这一努力的大量突出文献，而且还质疑JEV疫苗取得显著成功的基础，其中最重要的可能是易于预防JEV引起的脑炎。总而言之，对那些致力于病毒疫苗研究的人的独创性的真正考验将是对艾滋病毒/艾滋病和登革热等病毒性疾病的成功，这些疾病对科学家构成了更大的挑战。
As an eminently vaccine-preventable disease, encephalitis caused by Japanese encephalitis virus (JEV) has attracted an unusually high degree of attention from those seeking to develop viral vaccines. Since the 1950s, all types of JEV vaccines including inactivated, recombinant and live attenuated ones have been licensed. As an example of an extremely successful endeavour, the time is ripe for reviewing the development of JEV vaccines and probing the reasons behind their uniform success. Vaccines against JEV have come a long way since the first licensing in the mid-1950s of the mouse brain-grown-inactivated virus preparations, to the present day live-attenuated virus vaccines. A survey of the various inactivated and live vaccines developed against JEV provides a striking insight into the impressive safety and efficacy of all the vaccines available to prevent encephalitis from JEV. This review juxtaposes studies to understand naturally acquired immunity against JEV that have mostly been published post-2000, compares these with those elicited by vaccines and highlights the paucity of data on cell-mediated immune responses elicited by JEV vaccines. This article not only seeks to make available the immense salient literature on this endeavour in one collection, but also queries the basis for the remarkable success of JEV vaccines, not least of which may be the ease of protecting against encephalitis caused by JEV. To conclude, the true test of the ingenuity of those dedicated to the pursuit of viral vaccines would be success against viral diseases such as HIV-AIDS and dengue that pose a far greater challenge to scientists.
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影响因子：
4
作者：
Friberg, Heather;Burns, Lynne;Woda, Marcia;Kalayanarooj, Siripen;Endy, Timothy P.;Stephens, Henry A. F.;Green, Sharone;Rothman, Alan L.;Mathew, Anuja
通讯作者：
Mathew, Anuja
影响因子：
158.5
作者：
HOKE, CH;NISALAK, A;BURKE, DS
通讯作者：
BURKE, DS
影响因子：
5.4
作者：
Arroyo, J;Guirakhoo, F;Chambers, TJ
通讯作者：
Chambers, TJ
影响因子：
5.5
作者：
Eder, Susanne;Dubischar-Kastner, Katrin;Klade, Christoph S.
通讯作者：
Klade, Christoph S.
影响因子：
5.5
作者：
Erra, Elina O.;Askling, Helena Hervius;Kantele, Anu
通讯作者：
Kantele, Anu