Biomarkers of deep venous thrombosis
Biomarkers of deep venous thrombosis
复制标题
深静脉血栓形成的生物标志物
DOI：
10.1007/s11239-012-0721-y
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发表时间：
2012-10-01
影响因子：
4
通讯作者：
Jiang, Qing
中科院分区：
文献类型：
--
作者：
Hou, Huacheng;Ge, Zhijuan;Jiang, Qing
深静脉血栓形成（Deep venous thrombosis， DVT）是一种与肺栓塞相关的致命疾病，在门诊和住院患者，尤其是住院患者中发病率和死亡率都很高。同时，缺乏主观临床症状和客观临床体征，使诊断变得复杂。历史上，主要的成像方式，包括双超声、螺旋CT扫描和静脉造影，建立了DVT的诊断。目前，影像学和血清学两种方法都得到了应用。这些血浆分子包括d -二聚体、p -选择素、因子VIII、凝血酶生成、炎症因子、微粒、纤维蛋白单体、白细胞计数等，被认为是DVT的生物标志物。本文简要综述了生物标志物在深静脉血栓形成诊断和指导治疗中的作用。
Deep venous thrombosis (DVT), which is associated with pulmonary embolism, is a fatal disease because of its high morbidity and mortality in outpatients and inpatients, especially in hospitalized patients. At the same time, lack of subjective clinical symptoms and objective clinical signs makes the diagnosis complicated. Historically, the primarily imaging modalities, including duplex ultrasound, helical CT scans, and venography, establish the diagnosis of DVT. Currently, both imaging modalities and serology are utilized. These plasma molecules are regarded as the biomarkers of DVT including D-dimer, P-selectin, Factor VIII, thrombin generation, inflammatory cytokines, microparticles, fibrin monomer, leukocyte count and so on. This brief review is used to analyze the contribution of the biomarkers to diagnosis and guidance of therapy for DVT.