Cloning and characterization of a cDNA encoding the catalytic subunit of a cAMP-dependent protein kinase from Ancylostoma caninum third-stage infective larvae.

Cloning and characterization of a cDNA encoding the catalytic subunit of a cAMP-dependent protein kinase from Ancylostoma caninum third-stage infective larvae.
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编码犬钩虫第三阶段感染性幼虫 cAMP 依赖性蛋白激酶催化亚基的 cDNA 的克隆和表征。

DOI:
10.1016/0166-6851(94)00203-y
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发表时间:
1995
影响因子:
1.5
通讯作者:
Hotez,PJ
Hotez,PJ
中科院分区:
医学4区
文献类型:
--
作者:
Hawdon,JM;Jones,BF;Hotez,PJ

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The cDNA encoding the catalytic subunit of theAncylostoma caninumcAMP-dependent protein kinase represents the first signal transduction molecule reported from hookworms, and confirms the existence of a protein kinase A (PKA)-dependent pathway in these parasites. Also, the presence of the conserved nematode spliced leader on the 5′ end of AcPKA cDNA is the first report of the spliced leader from hookworms, and indicates thattrans-splicing of mRNA is involved in hookworm gene expression. The deduced amino acid sequence of the catalytic subunit consisted of 360 amino acids.
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