Identifying Cochlear Implant Channels With Relatively Poor Electrode-Neuron Interfaces Using the Electrically Evoked Compound Action Potential.
Identifying Cochlear Implant Channels With Relatively Poor Electrode-Neuron Interfaces Using the Electrically Evoked Compound Action Potential.
复制标题
使用电诱发复合动作电位识别具有相对较差的电极-神经元界面的皮质植入通道。
DOI：
10.1097/aud.0000000000000844
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Arenberg, Julie G.
中科院分区：
文献类型：
--
作者：
Jahn, Kelly N.;Arenberg, Julie G.
关键词：
本研究的主要目的是使用电诱发复合动作电位（ECAP）量化人工耳蜗（CI）电极-神经元界面（ENI）的局部（耳内）和全局（耳间）变化。我们测试了这一假设，即在一只耳朵内，ECAP测量可用于识别具有假定良好和不良ENI的通道，这可能受到SGN密度、电极位置和耳蜗电阻率的组合的影响。我们还假设，ECAP反应将反映年龄相关的差异，在全球质量的ENI之间的年轻和老年听众谁理论上不同的SGN密度。数据来自18只植入了Advanced Bionics HiRes 90 K设备的耳（13名个体）。6名参与者（8只耳朵）为青少年或年轻人（年龄范围：14至32岁），7名参与者（10只耳朵）为老年人（年龄范围：54至88岁）。在每只耳朵中，在通道2至15上测量单通道听觉检测阈值，以响应空间聚焦电极配置（转向四极;聚焦系数= 0.9）。在每只耳朵的一个通道子集上评估ECAP振幅、AGF斜率和阈值，以响应三个间期间隙（0、7和30 μs）。在2和15之间的所有通道上评估ECAP峰值幅度。在两个非相邻通道上测量幅度增长函数和ECAP阈值，其中每只耳朵的最低和最高聚焦行为阈值。ECAP的反应进行了比较，在低和高阈值的渠道，年轻和年长的CI听众。被估计为与听觉神经接口不良的通道（即，高聚焦阈值通道）具有比具有低聚焦阈值的通道更陡的ECAPAGF斜率、更小的动态范围和更高的ECAP阈值。年轻的听众比年长的听众有更陡的ECAP AGF斜率和更大的ECAP峰值幅度。此外，年轻的听众表现出更大的IPG灵敏度ECAP振幅比老年听众。ECAP响应可用于量化ENI质量的局部（耳内）和全局（耳间）变化。这项研究的结果支持未来的调查使用ECAP反应在选址CI编程策略。目前的结果还支持越来越多的证据表明，青少年和年轻人与CI可能有更密集的人口功能SGN相对于老年人。年轻和老年听众之间的全球SGN完整性的潜在差异值得调查的基础上，他们不同的听力历史的最佳CI编程干预。
The primary objective of this study was to quantify local (within-ear) and global (between-ear) variation in the cochlear implant (CI) electrode-neuron interface (ENI) using the electrically evoked compound action potential (ECAP). We tested the hypothesis that, within an ear, ECAP measures can be used to identify channels with presumed good and poor ENIs, which may be influenced by a combination of SGN density, electrode position, and cochlear resistivity. We also hypothesized that ECAP responses would reflect age-related differences in the global quality of the ENI between younger and older listeners who theoretically differ in SGN density. Data were obtained from 18 implanted ears (13 individuals) with Advanced Bionics HiRes 90K devices. Six participants (8 ears) were adolescents or young adults (age range: 14 to 32 years) and 7 participants (10 ears) were older adults (age range: 54 to 88 years). In each ear, single-channel auditory detection thresholds were measured on channels 2 through 15 in response to a spatially focused electrode configuration (steered quadrupolar; focusing coefficient = 0.9). ECAP amplitudes, AGF slopes, and thresholds were assessed on a subset of channels in each ear in response to three interphase gaps (0, 7 and 30 μs). ECAP peak amplitudes were assessed on all channels between 2 and 15. Amplitude growth functions and ECAP thresholds were measured on the two non-adjacent channels with the lowest and highest focused behavioral thresholds in each ear. ECAP responses were compared across low- and high-threshold channels and between younger and older CI listeners. Channels that were estimated to interface poorly with the auditory nerve (i.e., high-focused-threshold channels) had steeper ECAP AGF slopes, smaller dynamic ranges, and higher ECAP thresholds than channels with low focused thresholds. Younger listeners had steeper ECAP AGF slopes and larger ECAP peak amplitudes than older listeners. Moreover, younger listeners showed greater IPG sensitivity for ECAP amplitude than older listeners. ECAP responses may be used to quantify both local (within-ear) and global (between-ear) variation in the quality of the ENI. Results of this study support future investigation into the use of ECAP responses in site-selection CI programming strategies. The present results also support a growing body of evidence suggesting that adolescents and young adults with CIs may have denser populations of functional SGNs relative to older adults. Potential differences in global SGN integrity between younger and older listeners warrants investigation of optimal CI programming interventions based on their divergent hearing histories.