Lateral resolution enhancement of pulse-driven light-addressable potentiometric sensor
Lateral resolution enhancement of pulse-driven light-addressable potentiometric sensor
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DOI：
10.1016/j.snb.2017.02.057
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发表时间：
2017-09
影响因子：
8.4
通讯作者：
C. Werner;K. Miyamoto;T. Wagner;M. Schöning;T. Yoshinobu
中科院分区：
文献类型：
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作者：
C. Werner;K. Miyamoto;T. Wagner;M. Schöning;T. Yoshinobu
为了研究化学和生物过程，空间分辨测定一个或多个分析物物种的浓度具有明显的意义。利用光可寻址电位传感器(LAPS)，可以创建化学图像，直观地显示传感器板上方的浓度分布。一个重要的挑战是实现良好的横向分辨率，以便检测在一个小而有限的区域内发生的事件。LAPS利用聚焦光点来定位测量区域。通过沿半导体传感器板移动该光点，可以观察到浓度分布。在这项研究中，我们表明，用脉冲作为光激励，而不是传统上使用的连续调制光激励，可以将横向分辨率提高6倍或更多。
To study chemical and biological processes, spatially resolved determination of the concentrations of one or more analyte species is of distinct interest. With a light-addressable potentiometric sensor (LAPS), chemical images can be created, which visualize the concentration distribution above the sensor plate. One important challenge is to achieve a good lateral resolution in order to detect events that take place in a small and limited region. LAPS utilizes a focused light spot to address the measurement region. By moving this light spot along the semiconductor sensor plate, the concentration distribution can be observed. In this study, we show that utilizing a pulse as light excitation instead of a traditionally used continuously modulated light excitation, the lateral resolution can be improved by a factor of 6 or more.