Assignment of pancreatic eIF-2α kinase (EIF2AK3) to human chromosome band 2p12 by radiation hybrid mapping and in situ hybridization
Assignment of pancreatic eIF-2α kinase (EIF2AK3) to human chromosome band 2p12 by radiation hybrid mapping and in situ hybridization
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DOI：
10.1159/000015328
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发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Shi, Y
中科院分区：
文献类型：
--
作者：
Hayes, SE;Conner, LJ;Shi, Y
本文利用放射杂交定位和原位杂交技术，研究了胰腺eif2α激酶（EIF2AK3）在人类染色体2p12带的定位。胰岛eIF-2α激酶是eIF-2α激酶家族的新成员，该家族包括血调抑制剂激酶、双链RNA依赖蛋白激酶和酵母GCN2。EIF2AK3活性也与内质网应激反应有关。为了确定EIF2AK3表达的改变是否与可能的疾病状态有关，使用了辐射杂交作图和荧光原位杂交分析来定位EIF2AK3基因。
This article focuses on the localization of pancreatic eIF-2α kinase (EIF2AK3) to human chromosome band 2p12 by radiation hybrid mapping and in situ hybridization. The pancreatic eIF-2α kinase is a new member of a family of eIF-2α kinase, which include hemeregulated inhibitor kinase, the double stranded RNA dependent protein kinase, and the yeast GCN2. EIF2AK3 activity has also been linked to responsiveness to endoplasmic reticulum stress. To determine whether altered EIF2AK3 expression may he linked to a possible disease state, radiation hybrid mapping and fluorescent in situ hybridization analysis had been used to localize the EIF2AK3 gene.