MULTIPLE-MUTATION THEORY OF CARCINOGENESIS
MULTIPLE-MUTATION THEORY OF CARCINOGENESIS
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DOI：
10.1038/181651b0
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发表时间：
1958-01-01
期刊：
影响因子：
64.8
通讯作者：
FISHER, JC
中科院分区：
文献类型：
--
作者：
FISHER, JC
癌症发生的体细胞突变理论被赋予了新的生命，因为它认识到不仅仅需要一个，而是可能需要几个突变。Fisher和Hollomon1认为相邻细胞中的一些相似突变可能引发癌症，并推导出一个群体中癌症出现率的形式定律，p是临界大小组中的细胞数量。他们从死亡率数据中得出了接近7的p值。Muller 2和Nordling3认为，同一细胞中的一些连续突变可能引发癌症，并推导出癌症出现率的相同形式的规律，其中p77现在是单个细胞中所需的突变数量。
NEW life was given to the somatic mutation theory of carcinogenesis when it was recognized that not just one, but several mutations were probably required. Fisher and Hollomon1thought that a number of similar mutations in adjacent cells might initiate cancer, and deduced a law of the formfor the rate of appearance of cancers in a population, withpbeing the number of cells in the critical size group. They arrived at a value ofpnear 7 from the mortality data. Muller2and Nordling3thought that a number of successive mutations in the same cell might initiate cancer, and deduced a law of the same form,, for the rate of appearance of cancers, with p ≈ 7 now being the number of mutations required in a single cell.