Molecular computational elements encode large populations of small objects
Molecular computational elements encode large populations of small objects
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DOI：
10.1038/nmat1733
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发表时间：
2006-10-01
期刊：
影响因子：
41.2
通讯作者：
Weir, Sheenagh M.
中科院分区：
文献类型：
--
作者：
De Silva, A. Prasanna;James, Mark R.;Weir, Sheenagh M.
自从引入分子计算(1，2)以来，实验分子计算元素已经发展到包括小规模积分(6)、算术(7)和游戏(8)等。然而，对实际应用的需求一直很紧迫。在这里，我们提出了分子计算识别(MCID)，这证明了分子逻辑和计算可以应用于一个广泛相关的问题。在微观世界中需要编码的群体的例子是诊断中的细胞或组合化学(标签)中的珠子。利用分子逻辑门的小尺寸(9)(约1 nm)和大的开/关输出比，使用除颜色之外的各种逻辑类型、输入化学组合、开关阈值和偶数门阵列，我们为用于合成组合文库(10，11)的小聚合物小球(约100微米)的群体成员产生唯一的识别符。数以百万计的可区分标签变得可用。这种方法应该可以扩展到小得多的对象，唯一需要的是一个“清洗和监视”协议(12)。我们的重点是将分子科学转化为与模拟传感器(13，14)有关的技术，在本工作中转向数字逻辑器件。
Since the introduction of molecular computation(1,2), experimental molecular computational elements have grown(3-5) to encompass small-scale integration(6), arithmetic(7) and games(8), among others. However, the need for a practical application has been pressing. Here we present molecular computational identification (MCID), a demonstration that molecular logic and computation can be applied to a widely relevant issue. Examples of populations that need encoding in the microscopic world are cells in diagnostics or beads in combinatorial chemistry ( tags). Taking advantage of the small size(9) ( about 1 nm) and large 'on/off' output ratios of molecular logic gates and using the great variety of logic types, input chemical combinations, switching thresholds and even gate arrays in addition to colours, we produce unique identifiers for members of populations of small polymer beads ( about 100 mu m) used for synthesis of combinatorial libraries(10,11). Many millions of distinguishable tags become available. This method should be extensible to far smaller objects, with the only requirement being a 'wash and watch' protocol(12). Our focus on converting molecular science into technology concerning analog sensors(13,14), turns to digital logic devices in the present work.