The human cytotrophoblastic cell, a mononuclear chameleon
The human cytotrophoblastic cell, a mononuclear chameleon
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DOI：
10.1016/j.biocel.2004.05.014
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发表时间：
2005-01-01
影响因子：
4
通讯作者：
Irminger-Finger, I
中科院分区：
文献类型：
--
作者：
Bischof, P;Irminger-Finger, I
人类胎盘代表丰富；易于获取且不受限制的研究材料（出生时人胎盘提供约 500 克滋养层）。细胞滋养层细胞 (CTB) 是人类胎盘的组成部分之一，是具有迷人特性的上皮细胞：它们能够融合形成合胞体，可以表现得像不动的极化上皮细胞，可以对基质成纤维细胞或内皮细胞进行表型复制，或者进行类似间充质的转化，将它们转化为非增殖性和高度侵袭性的细胞。因此，像变色龙一样，CTB 能够通过对邻近细胞进行表型复制来适应其直接环境。这篇综述描述了 CTB 在分化途径中遵循的不同途径、在分子水平上的调节，还概述了与错误途径相关的病理学，并描述了用于识别不同 CTB 亚群的常用表型标记。本综述旨在激励不熟悉胎盘生物学领域的研究者使用CTB作为模型来研究体外重要的生物学功能，如细胞融合、细胞侵袭和细胞转化。 (C) 2004 Elsevier Ltd. 保留所有权利。
The human placenta represents an abundant; easily accessible and unlimited study material (at birth a human placenta provides about 500 g of trophoblast). Cytotrophoblastic cells (CTB) are one constituent of the human placenta and represent epithelial cells with fascinating properties: They are able to fuse to form syncytia, can behave like immotile polarized epithelial cells, can phenocopy stromal fibroblasts or endothelial cells or undergo a mesenchymal-like transformation that converts them into non proliferative and highly invasive cells. Like a chameleon, CTB are thus able to adapt to their immediate environment by phenocopying their neighbor cells.This review describes the different routes that CTB follow during their differentiation pathways, the regulation of these at the molecular level, it gives also an overview of the pathologies associated with faulty pathways and describes the usual phenotypic markers used to identify the different CTB subsets. This review is intended to stimulate investigators not acquainted with the field of placental biology to use CTB as a model to study important biological functions in vitro, such as cell fusion, cell invasion and cell transformation. (C) 2004 Elsevier Ltd. All rights reserved.