Recent Advances in the Synthesis of Deuterium‐Labeled Compounds
Recent Advances in the Synthesis of Deuterium‐Labeled Compounds
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DOI：
10.1002/ajoc.202100381
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发表时间：
2021-08
影响因子：
2.7
通讯作者：
Xiaoli Yang;Haoxi Ben;Arthur J. Ragauskas
中科院分区：
文献类型：
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作者：
Xiaoli Yang;Haoxi Ben;Arthur J. Ragauskas
氘标记化合物在化学、环境和生物领域具有重要意义。氘标记化合物的制备方法已被广泛研究，以应对对这些化学品日益增长的需求。在这篇综述中，我们总结了合成方法的最新进展，并对各种路线进行了全面的概述，包括传统的氘代和氢氘交换。介绍了从合适的标记前体开始的经典氘代反应的不同反应类型。从催化剂和底物化学结构的角度详细阐述了氢氘交换的关键特征。由于立体选择性氘标记在医学中的作用，在目标位置的区域选择性氘代进行了讨论。最后，这些方法的挑战和未来的前景进行了讨论，提供一个一般性的指导方针，氘标记化合物的合成。
Deuterium‐labeled compounds are of importance in chemical, environmental, and biological fields. Preparation methods for deuterium‐labeled compounds have been studied extensively in response to increasing demand for these chemicals. In this review, we summarize recent advances in synthetic methods and present a comprehensive overview of diverse routes, including conventional deuteration and hydrogen‐deuterium exchange. Deuteration by the classical process, which starts from appropriate available labeled precursors, is introduced for different reaction types. Key features of hydrogen‐deuterium exchange are elaborated in detail from the perspective of the catalyst and the chemical structure of the substrate. Regioselective deuteration at the target position is discussed because of the role of stereospecific deuterium labeling in medicine. Finally, challenges and future prospects of these processes are discussed to provide a general guideline for the synthesis of deuterium‐labeled compounds.