Mechanical Considerations of Bioprinted Tissue
Mechanical Considerations of Bioprinted Tissue
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DOI：
10.3389/fmech.2020.568726
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发表时间：
2020-10
期刊：
影响因子：
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通讯作者：
Hannah A Strobel;S. Moss;J. Hoying
中科院分区：
文献类型：
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作者：
Hannah A Strobel;S. Moss;J. Hoying
生物打印能够制造具有复杂特征的工程组织，有利于自动化组织制造和扩大规模。由于细胞系统和组织是动态的，并且对环境因素（包括生物力学刺激）非常敏感，因此生物打印组织的形式和功能在打印后可能会发生巨大变化。在这里，我们讨论与打印细胞系统和组织相关的组织生物力学，强调细胞行为、基质沉积和组织力之间的动态和复杂关系。此外，我们还提供了关于机械力的控制和操纵的观点，以及基于打印的方法和策略中组织结构的设计边界条件。
Bioprinting enables the fabrication of engineered tissues with complex features and is conducive to automated tissue manufacturing and scale up. As cell systems and tissues are dynamic and very responsive to environmental cues, including biomechanical stimuli, the form and function of bioprinted tissues can change dramatically after printing. Here, we discuss tissue biomechanics relevant to printed cell systems and tissues emphasizing the dynamic and complex relationship between cell behavior, matrix deposition, and tissue forces. Furthermore, we provide perspectives on the control and manipulation of mechanical forces and designed boundary conditions for tissue constructs in printing-based approaches and strategies.