THE EPIDEMIOLOGY OF KNEE OSTEOARTHRITIS - RESULTS FROM THE FRAMINGHAM OSTEOARTHRITIS STUDY
THE EPIDEMIOLOGY OF KNEE OSTEOARTHRITIS - RESULTS FROM THE FRAMINGHAM OSTEOARTHRITIS STUDY
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DOI：
10.1016/0049-0172(90)90046-i
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发表时间：
1990-12-01
影响因子：
5
通讯作者：
FELSON, DT
中科院分区：
文献类型：
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作者：
FELSON, DT
骨折性膝关节骨关节炎研究是一项基于人群的独立生活老年人研究，旨在检查影像学和症状性膝关节骨关节炎的患病率。这组在20世纪80年代初进行了评估，当时他们已经观察了35年以上，并确定了骨关节炎的许多风险因素。这项研究的结果表明，膝关节骨关节炎的患病率在老年人中增加，女性比男性更明显。此外，对风险因素的研究表明，肥胖先于并增加了膝关节骨关节炎的风险，特别是在女性中。骨折性骨关节炎研究记录的其他重要疾病风险因素包括膝关节损伤、软骨钙质沉着症、职业性膝关节弯曲和体力劳动。膝关节骨关节炎与吸烟呈负相关。在残疾方面，下肢功能障碍是常见的膝关节骨关节炎患者，但上肢功能障碍不是，和症状和严重程度的放射性骨关节炎与功能障碍的风险较高。
The Framingham Knee Osteoarthritis study is a population-based study of independently living elderly examining the prevalence of radiographic and symptomatic knee Osteoarthritis. This group was assessed in the early 1980s at which time they had been observed for over 35 years and many risk factors for Osteoarthritis had been ascertained. Results from this study suggest that knee osteoarthritis increases in prevalence throughout the elderly years, more so in women than in men. Also, studies of risk factors have shown that obesity precedes and increases the risk of knee osteoarthritis, especially in women. Other risk factors documented by the Framingham osteoarthritis study to be important as risk factors for disease include knee injury, chondrocalcinosis, and occupational knee bending and physical labor. Radiographie knee Osteoarthritis was negatively associated with smoking. No clearcut relationship of osteoarthritis with estrogen use in women was found. In terms of disability, lower extremity dysfunction is common in patients with knee osteoarthritis, but upper extremity dysfunction is not, and symptoms and severe degrees of radiographic Osteoarthritis are associated with higher risks of dysfunction.