Role of Micro-RNA for Pain After Surgery: Narrative Review of Animal and Human Studies.
Role of Micro-RNA for Pain After Surgery: Narrative Review of Animal and Human Studies.
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DOI：
10.1213/ane.0000000000004767
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发表时间：
2020-06
影响因子：
5.7
通讯作者：
Eltzschig HK
中科院分区：
文献类型：
--
作者：
Cata JP;Gorur A;Yuan X;Berg NK;Sood AK;Eltzschig HK
大手术后最常见的症状之一是疼痛。当术后疼痛治疗不满意时，可能会导致手术恢复不良、生活质量下降和医疗保健费用增加。目前的镇痛剂，无论是单一的还是联合的，由于效力低、作用持续时间有限、毒性和成瘾风险，其功效有限。非成瘾性强效镇痛剂的缺乏沿着阿片类药物的过度处方导致阿片类药物在美国流行。因此，迫切需要开发新的镇痛剂。微核糖核酸（miRNA）是一种小的非编码RNA分子，可调节神经元和支持细胞（神经胶质细胞、白细胞和许旺细胞）中的蛋白质合成。文献表明miRNA调控在伤害感受中是重要的。在这里，我们总结了目前有关miRNAs在切口疼痛、炎症疼痛、神经性疼痛和癌症疼痛机制中的作用的证据。我们还讨论了调节miRNA功能作为镇痛剂使用和阿片耐受性的潜在治疗靶点的作用。最后，我们提出了如何将类似物miRNAs（mimic-miRNAs或miRNAs）的递送引入临床实践，以在围手术期提供镇痛。
One of the most prevalent symptoms after major surgery is pain. When postoperative pain treatment is unsatisfactory, it can lead to poor surgical recovery, decreased quality of life, and increased health care costs. Current analgesics, single or in combination, have limited efficacy due to low potency, limited duration of action, toxicities, and risk of addiction. The lack of nonaddictive strong analgesics along with the over prescription of opioids has led to an opioid epidemic in the United States. Therefore, there is an urgent need for the development of newer analgesics. Microribonucleic acids (miRNAs) are small noncoding RNA molecules that modulate protein synthesis in neurons and supporting cells (glia, leukocytes, and Schwann cells). The literature indicates that miRNA regulation is important in nociception. Here, we summarize the current evidence on the role of miRNAs on mechanisms involved in incisional, inflammatory, neuropathic, and cancer pain. We also discuss the role of modulating miRNA functions as potential therapeutic targets for analgesic use and opioid tolerance. Finally, we propose how the delivery of analog miRNAs (mimic-miRNAs or antago-miRNAs) could be introduced into clinical practice to provide analgesia in the perioperative period.