THE EFFECT OF OESTROGENS ON HUMAN CALCITONIN SECRETION AFTER CALCIUM INFUSION IN ELDERLY FEMALE SUBJECTS
THE EFFECT OF OESTROGENS ON HUMAN CALCITONIN SECRETION AFTER CALCIUM INFUSION IN ELDERLY FEMALE SUBJECTS
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老年女性输钙后雌激素对人体降钙素分泌的影响
DOI：
10.1111/j.1365-2265.1980.tb01034.x
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发表时间：
1980
影响因子：
3.2
通讯作者：
Y. Kumahara
中科院分区：
文献类型：
--
作者：
S. Morimoto;Mitsuko Tsuji;Y. Okada;T. Onishi;Y. Kumahara
在 10 名老年女性中研究了雌激素给药（4-6 周）对人降钙素 (hCT) 分泌对 5 分钟钙输注的反应的影响。雌激素给药前后平均基础血浆 hCT 水平无显着差异。然而，钙输注后血浆 hCT 的平均增量 (ΔhCT) 显着增加 (P < 0·001)，从治疗前的 21·9±6·6（平均值±SE）增加到雌激素给药后的 79·6±15·5 ng/l。平均血清钙水平显着下降（P < 0·001），从雌激素治疗前的2·42 ±0·06 降至2·19·0±07 mmol/l。平均血浆免疫反应性 PTH (iPTH) 水平显着增加 (P < 0·05)，从雌激素治疗前的 521·41 到 696·96 ng/l。为了排除血清钙水平降低本身可能影响 ΔhCT 的可能性，将 1α-羟基胆钙化醇 (1α-OH-D3) 与雌激素一起给药。虽然这导致血清钙水平略有增加，但单独雌激素治疗后以及雌激素和 1 α-OH-D3 联合治疗后，ΔhCT 对钙输注的反应没有显着差异。施用雌激素的主要作用可能是刺激 hCT 分泌，从而导致血浆钙浓度降低和血浆 iPTH 水平增加。
The effect of oestrogen administration (4–6 weeks) on the response of human calcitonin (hCT) secretion to 5 min calcium infusions was studied in ten elderly women. There was no significant difference in mean basal plasma hCT levels before and after oestrogen administration. However, the mean increment in plasma hCT in response to calcium infusion (ΔhCT) increased significantly (P < 0·001) from 21·9±6·6 (mean ±SE) before treatment, to 79·6±15·5 ng/l after oestrogen administration. Mean serum calcium levels decreased significantly (P < 0·001) from 2·42 ±0·06 before to 2·19·0±07 mmol/l after oestrogen treatment. Mean plasma immunoreactive PTH (iPTH) levels increased significantly (P < 0·05) from 521·41 before to 696·96 ng/l after oestrogen treatment. To exclude out the possibility that the decreased serum calcium level itself might have influenced ΔhCT, 1α‐hydroxycholecalciferol (1α‐OH‐D3) was administered with oestrogens. While this resulted in a slight increase in serum calcium level, there was no significant difference in ΔhCT in response to calcium infusion following oestrogen treatment alone, and after combination therapy of oestrogen and 1 α‐OH‐D3. The primary action of administered oestrogen may be in stimulating hCT secretion which results in a decrease in plasma calcium concentration and an increase in plasma iPTH level.