Age-related effects of vagotonic atropine on cardiovagal baroreflex gain.
Age-related effects of vagotonic atropine on cardiovagal baroreflex gain.
复制标题
迷走神经阿托品对心脏迷走神经压力反射增益的年龄相关影响。
DOI：
10.1016/j.neurobiolaging.2010.03.018
复制
发表时间：
2012
影响因子：
4.2
通讯作者：
Taylor,JAndrew
中科院分区：
文献类型：
--
作者：
Callegaro,CarineC;Taylor,JAndrew
Impaired neural transduction of barosensory vessel stretch into vagal outflow is a primary determinant of reduced cardiovagal baroreflex gain with human aging. We set out to determine whether age-related reductions in this neural component of the baroreflex might be offset by enhancing the central integration/efferent responsiveness of the neural arc. Low vagotonic doses of atropine were employed to enhance central neural outflow and peripheral sinus node effects. Baroreflex gain and its neural and mechanical components were pharmacologically assessed before and after intravenous vagotonic atropine in 16 older and 14 young healthy subjects. Vagotonic atropine increased cardiovagal baroreflex gain (∼30%) and its neural component (∼20%) in older but not young individuals. Moreover, the atropine-induced increases in integrated gain and in its neural component were inversely related to baseline levels; across and within both groups, those with the lowest cardiovagal function demonstrated the greatest enhancement with vagotonic atropine. Thus, age-related neural deficits in the baroreflex arc appear to play a determining role in reduced cardiovagal baroreflex gain with age and the compromised neural baroreflex function can be acutely improved by a single pharmacologic intervention.
