Plasma carotenoids, vitamin C, retinol and tocopherols levels and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition: A nested case-control study Plasma micronutrients and pancreatic cancer risk
Plasma carotenoids, vitamin C, retinol and tocopherols levels and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition: A nested case-control study Plasma micronutrients and pancreatic cancer risk
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DOI：
10.1002/ijc.29175
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发表时间：
2015-03-15
影响因子：
6.4
通讯作者：
Bueno-de-Mesquita, H. B(as)
中科院分区：
文献类型：
--
作者：
Jeurnink, Suzanne M.;Ros, Martine M.;Bueno-de-Mesquita, H. B(as)
几种抗氧化剂和其他营养素对胰腺癌风险的保护作用的证据是不一致的。本研究的目的是研究诊断前血浆类胡萝卜素、维生素C、视黄醇和生育酚水平与胰腺癌风险的关系，这是欧洲癌症与营养前瞻性调查（EPIC）的一项病例对照研究。446例外分泌胰腺癌病例与446例对照，按采血年龄、研究中心、性别、采血日期和时间、禁食状态和激素使用情况进行匹配。用反相高效液相色谱法测定血浆类胡萝卜素（-和-胡萝卜素、番茄红素、-隐黄素、角黄素、玉米黄素和叶黄素）、-和-生育酚和视黄醇，用比色法测定血浆维生素C。采用条件logistic回归分析，对吸烟状况、吸烟持续时间和强度、腰围、可替宁水平和糖尿病状况进行校正，估计胰腺癌风险的95%置信区间发生率比（IRRs）。血浆-胡萝卜素（IRR最高比最低四分位数0.52,95%CI 0.31-0.88， p为趋势=0.02）、玉米黄质（IRR最高比最低四分位数0.53,95%CI 0.30-0.94， p为趋势=0.06）和-生育酚（IRR最高比最低四分位数0.62,95%CI 0.39-0.99， p为趋势=0.08）与胰腺癌风险呈负相关。对-胡萝卜素和-胡萝卜素、叶黄素、类胡萝卜素和-生育酚的总量，在地理区域之间存在异质性。总之，我们的研究结果表明，血浆中较高浓度的-胡萝卜素、玉米黄质和-生育酚可能与胰腺癌的风险呈负相关，但需要进一步的研究。有什么新鲜事吗?水果和蔬菜可能在预防胰腺癌中发挥作用，但这些食物所含的抗氧化剂与疾病风险之间的关系尚不清楚。在这项研究中，胰腺癌的风险与诊断前血浆中抗氧化剂-胡萝卜素、玉米黄质和-生育酚浓度的增加呈负相关。还发现了地理差异。在北欧国家，血液中几种类胡萝卜素的含量与风险呈负相关，而在南欧国家，-生育酚的含量与风险呈负相关。类胡萝卜素和维生素的作用应考虑在胰腺癌的病因的后续调查。
Evidence of a protective effect of several antioxidants and other nutrients on pancreatic cancer risk is inconsistent. The aim of this study was to investigate the association for prediagnostic plasma levels of carotenoids, vitamin C, retinol and tocopherols with risk of pancreatic cancer in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). 446 incident exocrine pancreatic cancer cases were matched to 446 controls by age at blood collection, study center, sex, date and time of blood collection, fasting status and hormone use. Plasma carotenoids (- and -carotene, lycopene, -cryptoxanthin, canthaxanthin, zeaxanthin and lutein), - and -tocopherol and retinol were measured by reverse phase high-performance liquid chromatography and plasma vitamin C by a colorimetric assay. Incidence rate ratios (IRRs) with 95% confidence intervals (95%CIs) for pancreatic cancer risk were estimated using a conditional logistic regression analysis, adjusted for smoking status, smoking duration and intensity, waist circumference, cotinine levels and diabetes status. Inverse associations with pancreatic cancer risk were found for plasma -carotene (IRR highest vs. lowest quartile 0.52, 95%CI 0.31-0.88, p for trend=0.02), zeaxanthin (IRR highest vs. lowest quartile 0.53, 95%CI 0.30-0.94, p for trend=0.06) and -tocopherol (IRR highest vs. lowest quartile 0.62, 95%CI 0.39-0.99, p for trend=0.08. For - and -carotene, lutein, sum of carotenoids and -tocopherol, heterogeneity between geographical regions was observed. In conclusion, our results show that higher plasma concentrations of -carotene, zeaxanthin and -tocopherol may be inversely associated with risk of pancreatic cancer, but further studies are warranted.What's new? Fruits and vegetables may play a role in the prevention of pancreatic cancer, but associations between the antioxidants those foods contain and disease risk remain unclear. In this study, pancreatic cancer risk was inversely associated with increased prediagnostic plasma concentrations of the antioxidants -carotene, zeaxanthin, and -tocopherol. Geographic variations were also detected. In Northern European countries, inverse associations with risk were found for blood levels of several carotenoids, whereas the association was strongest for -tocopherol in Southern European countries. The role of carotenoids and vitamins should be considered in subsequent investigations of the etiology of pancreatic cancer.