Pathogenicity of Chinese H5N1 highly pathogenic avian influenza viruses in pigeons
Pathogenicity of Chinese H5N1 highly pathogenic avian influenza viruses in pigeons
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DOI：
10.1007/s00705-008-0193-8
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发表时间：
2008-10-01
影响因子：
2.7
通讯作者：
Chen, Hualan
中科院分区：
文献类型：
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作者：
Jia, Beibei;Shi, Jianzhong;Chen, Hualan
长期以来，人们一直认为鸽子对H5高致病性禽流感病毒具有抵抗力。然而，最近，高致病性H5N1禽流感病毒已表现出独特的生物学特性，可能能够在鸽子中引起疾病。为了检测家鸽对最近的H5N1病毒的敏感性，我们使用2002年至2004年在中国分离的H5N1病毒接种鸽子。在接种后21天内，所有鸽子均存活，并从临时临床体征中完全恢复。然而，血清转化试验表明，几种病毒确实在鸽子中建立了感染，并在口咽和泄殖腔中引起一定量的病毒脱落。然而，病毒脱落和病毒来源之间没有明确的关系。病毒也不一致地从感染组的鸽子的各种器官中分离出来。病理检查显示，感染开始时为呼吸道炎症，后期在脑部造成最严重的损害。这些结果表明，鸽子对最近的亚洲H5N1高致病性禽流感易感，并可能成为包括人类在内的其他动物的感染源。
It has long been thought that pigeons are resistant against H5 highly pathogenic avian influenza (HPAI) viruses. Recently, however, highly pathogenic H5N1 avian influenza viruses have demonstrated distinct biological properties that may be capable of causing disease in pigeons. To examine the susceptibility of domestic pigeons to recent H5N1 viruses, we inoculated pigeons using H5N1 viruses isolated in China from 2002 to 2004. Within 21 days following inoculation, all pigeons had survived and fully recovered from temporary clinical signs. However, seroconversion assays demonstrated that several viruses did in fact establish infection in pigeons and caused a certain amount of viral shedding in the oropharynx and cloaca. There was not, however, a definitive relationship between viral shedding and viral origin. Viruses were also inconsistently isolated from various organs of pigeons in infected groups. Pathological examination revealed that the infection had started as respiratory inflammation and caused the most severe lesions in the brain in later stages. These results indicate that pigeons are susceptible to the more recent Asian H5N1 HPAI and could be a source of infection to other animals, including humans.