Biomarkers and insulin sensitivity in women with Polycystic Ovary Syndrome: Characteristics and predictive capacity
Biomarkers and insulin sensitivity in women with Polycystic Ovary Syndrome: Characteristics and predictive capacity
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DOI：
10.1111/cen.12619
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发表时间：
2015-07-01
影响因子：
3.2
通讯作者：
Stepto, Nigel K.
中科院分区：
文献类型：
--
作者：
Cassar, Samantha;Teede, Helena J.;Stepto, Nigel K.
多囊卵巢综合征（PCOS）是一种常见的内分泌疾病，伴有代谢性并发症。代谢生物标志物在肥胖、血脂控制和脂质代谢中的作用与PCOS可能相关。目的是研究肥胖和肥胖妇女的代谢生物标志物，并确定是否有任何生物标志物能够预测PCOS的胰岛素抵抗。设计横断面研究。（22名超重和22名瘦型PCOS妇女，18名超重和22名非PCOS的瘦女性）主要结果是代谢生物标志物[生长激素释放肽、内脂素、胰高血糖素样肽-1（GLP-1）、瘦素，纤溶酶原激活物抑制剂-1（派-1），葡萄糖依赖性促胰岛素分泌多肽（GIP）和C肽]测量使用Bio-Glucose Pro糖尿病检测和胰岛素敏感性评估葡萄糖输注率对eukaryoemic-hyperinsulinaemic clamp.ResultsThe生物标志物C肽，瘦素，生长素释放肽和visfatin是不同的超重和瘦的妇女，不论PCOS状态。根据鹿特丹标准或国立卫生研究院标准诊断的PCOS患者之间循环生物标志物浓度无差异。派-1是唯一的生物标志物，显着预测胰岛素抵抗的控制妇女（P= 0.04）和妇女与PCOS（P= 0.01）。派-1也可能是一种新的独立的生物标志物和预测胰岛素抵抗的妇女与非PCOS。
ObjectivePolycystic ovary syndrome (PCOS) is a common endocrine disorder associated with metabolic complications. Metabolic biomarkers with roles in obesity, glycaemic control and lipid metabolism are potentially relevant in PCOS. The aim was to investigate metabolic biomarkers in lean and overweight women with and without PCOS and to determine whether any biomarker was able to predict insulin resistance in PCOS.DesignCross-sectional study.PatientsEighty-four women (22 overweight and 22 lean women with PCOS, 18 overweight and 22 lean women without PCOS) were recruited from the community and categorized based on PCOS and BMI status.MeasurementsPrimary outcomes were metabolic biomarkers [ghrelin, resistin, visfatin, glucagon-like peptide-1 (GLP-1), leptin, plasminogen activator inhibitor -1 (PAI-1), glucose-dependent insulinotropic polypeptide (GIP) and C-Peptide] measured using the Bio-Plex Pro Diabetes assay and insulin sensitivity as assessed by glucose infusion rate on euglycaemic-hyperinsulinaemic clamp.ResultsThe biomarkers C-peptide, leptin, ghrelin and visfatin were different between overweight and lean women, irrespective of PCOS status. The concentration of circulating biomarkers did not differ between women with PCOS diagnosed by the Rotterdam criteria or National Institute of Health criteria. PAI-1 was the only biomarker that significantly predicted insulin resistance in both control women (P=004) and women with PCOS (P=001).ConclusionsBiomarkers associated with metabolic diseases appear more strongly associated with obesity rather than PCOS status. PAI-1 may also be a novel independent biomarker and predictor of insulin resistance in women with and without PCOS.