Highly Conductive Stretchable and Biocompatible Electrode-Hydrogel Hybrids for Advanced Tissue Engineering
Highly Conductive Stretchable and Biocompatible Electrode-Hydrogel Hybrids for Advanced Tissue Engineering
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DOI：
10.1002/adhm.201400209
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发表时间：
2014-11-01
影响因子：
10
通讯作者：
Nishizawa, Matsuhiko
中科院分区：
文献类型：
--
作者：
Sasaki, Masato;Karikkineth, Bijoy Chandapillai;Nishizawa, Matsuhiko
基于水凝胶的分子可渗透电子设备被认为是有前途的电刺激和活体组织的记录，无论是在体内还是在体外。本研究报告了第一种基于水凝胶的装置的制造，该装置在大幅度拉伸和弯曲下仍保持高导电性。利用化学聚合和电聚合相结合的简单技术，将聚（3,4-乙烯二氧噻吩）（PEDOT）和聚氨酯（PU）的导电复合材料与弹性双网水凝胶紧密结合，制成了完全有机的PEDOT/PU-水凝胶杂化物。它们对反复弯曲、机械拉伸、水化干燥循环、在水条件下储存长达6个月以及高压灭菌的反应进行了评估，显示出出色的稳定性，没有任何机械或电气损伤。在100%伸长率下，杂种材料的电导率高达120 S cm（-1）。在这些杂交体上培养的神经和肌肉细胞的粘附、增殖和分化，以及3D杂交体的制造，推动了组织工程与集成电子领域的发展。
Hydrogel-based, molecular permeable electronic devices are considered to be promising for electrical stimulation and recording of living tissues, either in vivo or in vitro. This study reports the fabrication of the first hydrogel-based devices that remain highly electrically conductive under substantial stretch and bending. Using a simple technique involving a combination of chemical polymerization and electropolymerization of poly (3,4-ethylenedioxythiophene) (PEDOT), a tight bonding of a conductive composite of PEDOT and polyurethane (PU) to an elastic double-network hydrogel is achieved to make fully organic PEDOT/PU-hydrogel hybrids. Their response to repeated bending, mechanical stretching, hydration-dessication cycles, storage in aqueous condition for up to 6 months, and autoclaving is assessed, demonstrating excellent stability, without any mechanical or electrical damage. The hybrids exhibit a high electrical conductivity of up to 120 S cm(-1) at 100% elongation. The adhesion, proliferation, and differentiation of neural and muscle cells cultured on these hybrids are demonstrated, as well as the fabrication of 3D hybrids, advancing the field of tissue engineering with integrated electronics.