Bilateral Acupuncture Analgesia Observed by Quantitative Sensory Testing in Healthy Volunteers
Bilateral Acupuncture Analgesia Observed by Quantitative Sensory Testing in Healthy Volunteers
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DOI：
10.1213/ane.0b013e3181d3e7ef
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发表时间：
2010-05-01
影响因子：
5.7
通讯作者：
Irnich, Dominik
中科院分区：
文献类型：
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作者：
Lang, Philip M.;Stoer, Johanna;Irnich, Dominik
背景技术背景：有证据表明，针刺激活不同的脊髓和脊髓上的抗伤害性系统，但具体的调制效应的感觉系统还没有系统的研究。在这项研究中，我们评估了不同类型的针刺对热，机械和振动感觉阈值的即时影响。（12名男性和12名女性，平均年龄33.1岁）在单盲交叉设计中接受了3种不同形式的针灸;这些方法包括手工针灸、低频电刺激针灸和高频电刺激针灸。干预之间的时间为1周。所有形式的针灸都是在标准穴位：脾6，脾9，胃36和胆囊39的腿部单侧应用。每次干预后立即通过系统定量感觉测试（QST）评估针刺的效果。结果：手针治疗侧和非治疗侧的热痛阈值均较治疗前升高，而热痛阈值与治疗前相比无显著性差异（P> 0.05）。与基线和手动针灸相比，低频和高频电刺激导致治疗侧的机械疼痛阈值更高。结论：3种常用针刺刺激方法均能提高QST，且有单侧效应，也有双侧效应。（Anesth Analg 2010;110：1448-56）
BACKGROUND: There is evidence that acupuncture activates different spinal and supraspinal antinociceptive systems, but the specific modulatory effects on the sensory system have not been systematically investigated. In this study, we evaluated the immediate effects of different types of acupuncture on thermal, mechanical, and vibratory sensory thresholds.METHODS: Twenty-four healthy volunteers (12 men and 12 women, mean age 33.1 years) received 3 different forms of acupuncture in a single-blinded crossover design; these included manual acupuncture, acupuncture with low-frequency electrical stimulation, and acupuncture with high-frequency electrical stimulation. The time between the interventions was 1 week. All forms of acupuncture were applied unilaterally in the leg at standard acupuncture points: spleen 6, spleen 9, stomach 36, and gallbladder 39. The effects of acupuncture were evaluated by systematic quantitative sensory testing (QST) immediately after each intervention. QST was performed on bilateral lower extremities, including thermal and mechanical perception and pain and vibratory thresholds.RESULTS: The heat pain threshold was increased after manual acupuncture on the treated and untreated side compared with baseline. Low- and high-frequency electrostimulation led to a higher mechanical pain threshold on the treated side compared with baseline and manual acupuncture. The pressure pain threshold was increased by all forms of acupuncture on both sides, with individual changes from baseline ranging from 25% to 52%.CONCLUSIONS: There were congruent changes on QST after 3 common acupuncture stimulation methods, with possible unilateral as well as bilateral effects. (Anesth Analg 2010;110:1448-56)