Secondary Metabolites Produced by Combined Culture of Penicillium crustosum and a Xylaria sp.
Secondary Metabolites Produced by Combined Culture of Penicillium crustosum and a Xylaria sp.
复制标题
甲壳青霉和 Xylaria sp 联合培养产生的次生代谢物。
DOI：
10.1021/acs.jnatprod.9b00345
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发表时间：
2019-07-01
影响因子：
5.1
通讯作者：
Li, Dehai
中科院分区：
文献类型：
--
作者：
Yu, Guihong;Sun, Zichao;Li, Dehai
从南极深海青霉菌PRB-2和红树林真菌Xylaria sp.的混合培养中分离得到4个新的烷基芳香族化合物--青霉素A-D(1-4)，以及已知的生物起源相关的1，3-二羟基-5-(12-羟基十七烷基)苯(5)和1，3-二羟基-5-(12-磺氧基十七烷基)苯(6).HDN13-249。UPLC-MS数据和结构特征分析表明，化合物1和2是由两种真菌共同产生的，而化合物3-6是由Xylaria sp.产生的。仅HDN13-249，但通过共培养显著增加了数量。化合物2、3、5和6对一组菌株具有抗菌活性，化合物3对草分枝杆菌具有潜在的抗结核作用(MIC=6.25μM)。
Four new alkyl aromatics, penixylarins A-D (1-4), along with the known biogenetically related 1,3-dihydroxy-5-(12-hydroxyheptadecyl)benzene (5) and 1,3-dihydroxy-5-(12-sulfoxyheptadecyl)benzene (6), were isolated from a mixed culture of the Antarctic deep-sea-derived fungus Penicillium crustosum PRB-2 and the mangrove-derived fungus Xylaria sp. HDN13-249. UPLC-MS data and an analysis of structural features showed that compounds 1 and 2 were produced by collaboration of the two fungi, while compounds 3-6 could be produced by Xylaria sp. HDN13-249 alone, but in noticeably increased quantities by cocultivation. Compounds 2, 3, 5, and 6 showed antibacterial activity against a panel of strains, and compound 3 possessed potential antituberculosis effects (MIC = 6.25 μM against Mycobacterium phlei).