DNA microarray analysis of human coronary artery endothelial cells exposed to cadmium.

DNA microarray analysis of human coronary artery endothelial cells exposed to cadmium.
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DOI：
10.2131/jts.36.141
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发表时间：
2011-02
期刊：
The Journal of toxicological sciences
影响因子：
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通讯作者：
Y. Fujiwara;Akiko Honda;C. Yamamoto;T. Kaji;M. Satoh
Y. Fujiwara;Akiko Honda;C. Yamamoto;T. Kaji;M. Satoh
中科院分区：
其他
文献类型：
--
作者：
Y. Fujiwara;Akiko Honda;C. Yamamoto;T. Kaji;M. Satoh

文献摘要

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镉(Cd)是一种有毒的重金属，已被证明会导致血管疾病，如动脉粥样硬化。我们使用DNA微阵列来监测人冠状动脉内皮细胞(HCAEC)对非致死剂量Cd(10µM)的转录反应。在35,035个人类基因中，Cd上调了MT1E、MT1H和MT1B等3个金属硫蛋白(MT)-I亚型基因的表达，下调了ISG20和TK1等12个基因的表达2倍以上。
Cadmium (Cd) is a toxic heavy metal that has been shown to induce vascular diseases, such as atherosclerosis. We used DNA microarray to monitor the transcriptional response of human coronary artery endothelial cells (HCAEC) to a non-lethal dose of Cd (10 µM). Out of 35,035 human genes, Cd enhanced the expression of 3 metallothionein (MT)-I subisoform genes, including MT1E, MT1H and MT1B, and reduced the expression of 12 genes, including ISG20 and TK1, 2-fold or greater.