Risk behaviors in a rural community with a known point-source exposure to chronic wasting disease.
Risk behaviors in a rural community with a known point-source exposure to chronic wasting disease.
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DOI：
10.1186/1476-069x-7-31
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发表时间：
2008-06-24
期刊：
影响因子：
--
通讯作者：
Shilkret K
中科院分区：
文献类型：
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作者：
Garruto RM;Reiber C;Alfonso MP;Gastrich H;Needham K;Sunderman S;Walker S;Weeks J;Derosa N;Faisst E;Dunn J;Fanelli K;Shilkret K
鹿科动物中慢性消耗性疾病 (CWD) 的出现和持续传播现已蔓延到美国 14 个州、加拿大两个省和韩国，这使得 CWD 朊病毒有可能在全球范围内传播给人类和其他动物。 2005年，CWD首次从中西部蔓延到东海岸人口更稠密的地区。结果，一大群在纽约州北部参加野味盛宴的人接触到了一只鹿，该鹿随后被证实患有 CWD 阳性。这项研究招募了 81 名在纽约州当地运动员盛宴上摄入或以其他方式接触过患有慢性消耗性疾病的鹿的参与者。参与者接受了暴露调查问卷，并同意在未来六年内纵向跟踪健康评估。我们的结果表明，参加盛宴的人面临两种类型的风险：盛宴风险和一般风险。危险因素越多，如果 CWD 传染给人类，对人类健康的风险就越大。对患有 CWD 的宴会参与者的长期监测正在进行中。这项研究的风险数据提供了累积暴露于 CWD 感染的组织和表面的相对范围，如果 CWD 可传染给人类，那些处于累积风险较高层的人可能面临最大的风险。
The emergence and continuing spread of Chronic Wasting Disease (CWD) in cervids has now reached 14 U.S. states, two Canadian provinces, and South Korea, producing a potential for transmission of CWD prions to humans and other animals globally. In 2005, CWD spread for the first time from the Midwest to more densely populated regions of the East Coast. As a result, a large cohort of individuals attending a wild game feast in upstate New York were exposed to a deer that was subsequently confirmed positive for CWD. Eighty-one participants who ingested or otherwise were exposed to a deer with chronic wasting disease at a local New York State sportsman's feast were recruited for this study. Participants were administered an exposure questionnaire and agreed to follow-up health evaluations longitudinally over the next six years. Our results indicate two types of risks for those who attended the feast, a Feast Risk and a General Risk. The larger the number of risk factors, the greater the risk to human health if CWD is transmissible to humans. Long-term surveillance of feast participants exposed to CWD is ongoing. The risk data from this study provide a relative scale for cumulative exposure to CWD-infected tissues and surfaces, and those in the upper tiers of cumulative risk may be most at risk if CWD is transmissible to humans.