Growth of group IV mycobacteria on medium containing various saturated and unsaturated fatty acids
Growth of group IV mycobacteria on medium containing various saturated and unsaturated fatty acids
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IV 族分枝杆菌在含有各种饱和和不饱和脂肪酸的培养基上的生长
DOI：
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发表时间：
1984
影响因子：
4.9
通讯作者：
T. Yoneyama
中科院分区：
文献类型：
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作者：
H. Saito;H. Tomioka;T. Yoneyama
用琼脂稀释法研究了15种快速生长分枝杆菌71株对2 ~ 20个碳原子的脂肪酸的敏感性。除了潜在病原体之外的大多数分枝杆菌（偶发分枝杆菌和龟分枝杆菌）对饱和脂肪酸具有抗性，除了月桂酸（C12：0）（MIC，6.25至25微克/毫升）和癸酸（C10：0）（MIC，50至100微克#毫升）。M. fortutuplant和M.龟类基本上对这些脂肪酸不敏感。除C20：5外，具有16至20个碳的不饱和脂肪酸对除M之外的IV组分枝杆菌具有高毒性。fortupe，M.龟分枝杆菌（Mycobacterium chelonei）、耻垢分枝杆菌（Mycobacterium smegalovirus）和草分枝杆菌（Mycobacterium phlei），这些对除C16：1、C18：3和C20：5之外的所有不饱和酸都具有高度抗性。引入双键的C16至C20脂肪酸引起了显着的增加，其活动取决于双键的数量的增加，至少高达三个或四个。M. fortutuplant和M.龟类分枝杆菌对不饱和脂肪酸（特别是C20：3和C20：4）的耐药性高于其他IV组分枝杆菌。
Seventy-one strains of 15 species of rapidly growing mycobacteria were studied for their susceptibilities to fatty acids with 2 to 20 carbons by the agar dilution method at pH 7.0. Most mycobacteria other than potential pathogens (Mycobacterium fortuitum and Mycobacterium chelonei) were resistant to saturated fatty acids, except for lauric acid (C12:0) (MIC, 6.25 to 25 micrograms/ml) and capric acid (C10:0) (MIC, 50 to 100 micrograms#ml). M. fortuitum and M. chelonei were substantially insusceptible to these fatty acids. Unsaturated fatty acids with 16 to 20 carbons, except for C20:5, were highly toxic to group IV mycobacteria other than M. fortuitum, M. chelonei, Mycobacterium smegmatis, and Mycobacterium phlei, these being highly resistant to all the unsaturated acids, except for C16:1, C18:3, and C20:5. Introduction of double bonds to C16 to C20 fatty acids caused a marked increase in their activities that depended on the increase in the number of double bonds, at least up to three or four. M. fortuitum and M. chelonei were more resistant to the unsaturated fatty acids (particularly to C20:3 and C20:4) than the other group IV mycobacteria.