Toll-like receptors in leishmania infections: guardians or promoters?
Toll-like receptors in leishmania infections: guardians or promoters?
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DOI：
10.1155/2012/930257
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发表时间：
2012
影响因子：
2.2
通讯作者：
Lima AP
中科院分区：
文献类型：
--
作者：
Faria MS;Reis FC;Lima AP
利什曼原虫属的原生动物根据寄生虫种类引起从自愈性皮肤损伤到内脏损伤的多种病理。感染的结果取决于适应性免疫反应的质量，这是由寄生虫因素和宿主遗传背景决定的。先天性反应，导致产生具有抗利什曼原虫活性的介质，有助于寄生虫控制，并有助于有效的适应性反应的发展。其中，大约十年前开始研究Toll样受体（TLR）家族成员在控制利什曼原虫感染中的潜在贡献。尽管大多数研究都认为TLR具有保护作用，但越来越多的证据表明，在某些情况下，TLR会促进感染。本文综述了利什曼原虫感染过程中TLR功能的最新进展，并讨论了其在抑制寄生虫生长与产生疾病方面的潜在作用。
Protozoa of the genus Leishmania cause a wide variety of pathologies ranging from self-healing skin lesions to visceral damage, depending on the parasite species. The outcome of infection depends on the quality of the adaptive immune response, which is determined by parasite factors and the host genetic background. Innate responses, resulting in the generation of mediators with anti-leishmanial activity, contribute to parasite control and help the development of efficient adaptive responses. Among those, the potential contribution of members of the Toll-like receptors (TLRs) family in the control of Leishmania infections started to be investigated about a decade ago. Although most studies appoint a protective role for TLRs, there is growing evidence that in some cases, TLRs facilitate infection. This review highlights recent advances in TLR function during Leishmania infections and discusses their potential role in restraining parasite growth versus yielding disease.