An implication of Klotho-related molecules in different smoking-related health outcomes between men and women
An implication of Klotho-related molecules in different smoking-related health outcomes between men and women
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DOI：
10.1016/j.cca.2017.11.007
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发表时间：
2018-01-01
影响因子：
5
通讯作者：
Yamauchi-Takihara, Keiko
中科院分区：
文献类型：
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作者：
Nakanishi, Kaori;Nishida, Makoto;Yamauchi-Takihara, Keiko
背景资料：男性和女性对某些疾病的反应不同，据报道，女性对吸烟的毒性作用比男性更敏感。我们检测了Klotho相关分子的血清浓度，（α K1）和成纤维细胞生长因子（FGF）-21，以及吸烟对这些分子在两种性别中的影响。方法：受试者包括90名男性和140名女性，他们健康状况良好，接受了健康检查。在男性受试者中，吸烟者的FGF-21、可溶性s α Kl和炎症相关细胞因子白细胞介素（IL）-6的血清浓度显著高于从不吸烟者。在女性中，吸烟者的FGF-21和IL-6血清浓度显著高于从不吸烟者;然而，吸烟者的s α Kl浓度略低于从不吸烟者。s α Kl的血清浓度仅在男性受试者中与吸烟状态和IL-6相关，表明s α Kl仅在男性中具有抗炎作用。FGF-21的血清浓度与总胆固醇，甘油三酯和HbA 1c的浓度，这是在女性代谢紊乱的重要因素，这表明代谢紊乱在女性吸烟者可能比在男性smoker.Conclusions：Klotho相关分子表现出不同的关联和响应男性和女性之间的吸烟。
Background: Men and women react differently to some disease states, and women are reported to be more sensitive than men to the toxic effects of smoking. We examined the serum concentration of Klotho-related molecules, alpha-Klotho (alpha Kl) and fibroblast growth factor (FGF)-21, and the influence of smoking on these molecules in both sexes.Methods: Subjects included 90 men and 140 women in good health who underwent a health examination.Results: Among male subjects, serum concentrations of FGF-21, soluble s alpha Kl, and inflammation-related cytokine interleukin (IL)-6 were significantly higher in smokers than in never-smokers. In females, serum concentrations of FGF-21 and IL-6 were significantly higher in smokers than in never-smokers; however, s alpha Kl concentrations were slightly lower in smokers than in never-smokers. Serum concentrations of s alpha Kl were correlated with smoking status and IL-6 only in male subjects, suggesting an anti-inflammatory effect of s alpha Kl only in men. Serum concentrations of FGF-21 were correlated with the concentrations of total cholesterol, triglycerides, and HbA1c, which are important factors of metabolic disorders in females, suggesting that metabolic disorders in female smokers may be more serious than that in male smokers.Conclusions: Klotho-related molecules showed a differential association and response to smoking between men and women.