Host-specificity of Salmonella enterica serovar Gallinarum: Insights from comparative genomics
Host-specificity of Salmonella enterica serovar Gallinarum: Insights from comparative genomics
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DOI：
10.1016/j.meegid.2009.01.004
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发表时间：
2009-07-01
影响因子：
3.2
通讯作者：
Chakravortty, Dipshikha
中科院分区：
文献类型：
--
作者：
Eswarappa, Sandeepa M.;Janice, Jessin;Chakravortty, Dipshikha
在本研究中，我们已经确定了可能的遗传因素负责鸡沙门氏菌（S。Gallinarum）。通过对沙门氏菌致病岛（SPI）相关基因的比较。鸡沙门氏菌（Salmonella enterica serovar Enteritrium，S.我们已经确定了24个积极选择的基因。我们的研究结果表明，编码SPI-2编码的第三型分泌器（TTSS）的结构组件的基因和通过SPI-1编码的TTSS分泌的效应蛋白已经在这些血清型中的正选择压力下进化。我们认为这些正选择基因在赋予沙门氏菌不同的宿主特异性中起着重要作用。Gallinarum和S.肠道。(C)2009 Elsevier B. V.保留所有权利。
In this study, we have identified the possible genetic factors responsible for fowl-adaptation of Salmonella enterica serovar Gallinarum (S. Gallinarum). By comparing the genes related to Salmonella pathogenicity islands (SPI) of S. Gallinarum with those of Salmonella enterica serovar Enteritidis (S. Enteritidis) we have identified twenty-four positively selected genes. Our results suggest that the genes encoding the structural components of SPI-2 encoded type three secretion apparatus (TTSS) and the effector proteins that are secreted via SPI-1 encoded TTSS have evolved under positive selection pressure in these serovars. We propose that these positively selected genes play important roles in conferring different host-specificities to S. Gallinarum and S. Enteritidis. (C) 2009 Elsevier B.V. All rights reserved.