Mast cells' involvement in inflammation pathways linked to depression: evidence in mastocytosis
Mast cells' involvement in inflammation pathways linked to depression: evidence in mastocytosis
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DOI：
10.1038/mp.2015.216
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发表时间：
2016-11-01
影响因子：
11
通讯作者：
Gaillard, R.
中科院分区：
文献类型：
--
作者：
Georgin-Lavialle, S.;Moura, D. S.;Gaillard, R.
越来越多的证据表明，炎症在抑郁、疲劳和认知功能障碍的发展中起作用。更确切地说，色氨酸（TRP）催化剂被认为在炎症诱导的抑郁症中起主要作用。肥大细胞增多症是一种罕见的疾病，其中慢性症状，包括抑郁症，与肥大细胞的积累和激活。我们的目的是研究肥大细胞增多症的神经精神特征和TRP catalysts通路之间的相关性，以证明肥大细胞在炎症诱导的抑郁症中的潜在参与。54例平均年龄为50.1岁的肥大细胞增多症患者参加了这项研究，并与年龄匹配的健康对照组进行了比较。采用贝克抑郁量表修订版和知觉压力量表评估抑郁和压力。所有患者均测量TRP、5-羟色胺（5-HT）、犬尿氨酸（KYN）、吲哚胺2，3-双加氧酶1（IDO 1）活性（KYN/TRP比值）、犬尿烯酸（KA）和喹啉酸（QA）。患者显示TRP和5-HT水平显著降低，无低白蛋白血症或吸收不良，IDO 1活性较高，KA和QA水平较高，后者失衡。高感知压力和高抑郁评分与低TRP和高IDO 1活性相关。总之，TRP代谢在肥大细胞增多症中改变，并与感知的压力和抑郁相关，表明肥大细胞参与与抑郁相关的炎症途径。
Converging sources of evidence point to a role for inflammation in the development of depression, fatigue and cognitive dysfunction. More precisely, the tryptophan (TRP) catabolism is thought to play a major role in inflammation-induced depression. Mastocytosis is a rare disease in which chronic symptoms, including depression, are related to mast cell accumulation and activation. Our objectives were to study the correlations between neuropsychiatric features and the TRP catabolism pathway in mastocytosis in order to demonstrate mast cells' potential involvement in inflammation-induced depression. Fifty-four patients with mastocytosis and a mean age of 50.1 years were enrolled in the study and compared healthy age-matched controls. Depression and stress were evaluated with the Beck Depression Inventory revised and the Perceived Stress Scale. All patients had measurements of TRP, serotonin (5-HT), kynurenine (KYN), indoleamine 2,3-dioxygenase 1 (IDO1) activity (ratio KYN/TRP), kynurenic acid (KA) and quinolinic acid (QA). Patients displayed significantly lower levels of TRP and 5-HT without hypoalbuminemia or malabsorption, higher IDO1 activity, and higher levels of KA and QA, with an imbalance towards the latter. High perceived stress and high depression scores were associated with low TRP and high IDO1 activity. In conclusion, TRP metabolism is altered in mastocytosis and correlates with perceived stress and depression, demonstrating mast cells' involvement in inflammation pathways linked to depression.