Decoding 3-D reach and grasp kinematics from high-frequency local field potentials in primate primary motor cortex.
Decoding 3-D reach and grasp kinematics from high-frequency local field potentials in primate primary motor cortex.
复制标题
从灵长类动物原发性运动皮层中的高频局部田间电位中解码3-D覆盖范围并掌握了运动学。
DOI：
10.1109/tbme.2010.2047015
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发表时间：
2010-07
期刊：
影响因子：
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通讯作者：
Donoghue JP
中科院分区：
文献类型：
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作者：
Zhuang J;Truccolo W;Vargas-Irwin C;Donoghue JP
皮层内微电极阵列记录产生各种神经信号，作为神经接口系统中的控制信号具有潜在的应用前景。以前的研究集中于单单位和多单位活动，以及低频局部场电位(LFP)，但没有探索更高频率(>；200赫兹)LFP。此外，基于LFPS的解码三维(3-D)伸展和抓取运动学的潜力还没有被证明。在这里，我们使用互信息和译码分析来探索在0.3-400 Hz范围内7个不同LFP频段的3-D到达和掌握的信息量。通过96个微电极阵列记录两只猴子在自由伸手抓握运动物体时的初级运动皮质(M1)的LFP。互信息分析表明，较高的频段(例如100-200赫兹和200-400赫兹)携带了关于所检查运动学的最多信息。此外，卡尔曼滤波解码表明，宽带高频LFP可能反映了多个单元的活动，在重建REACH运动学、抓取孔径和孔径速度方面提供了最好的解码性能和相当高的精度。这些结果表明，LFP，特别是高频段，可能是控制三维伸展和抓取运动学的神经接口的有用信号。
Intracortical microelectrode array recordings generate a variety of neural signals with potential application as control signals in neural interface systems. Previous studies have focused on single and multiunit activity, as well as low frequency local field potentials (LFPs), but have not explored higher frequency (>200 Hz) LFPs. In addition, the potential to decode three dimensional (3-D) reach and grasp kinematics based on LFPs has not been demonstrated. Here, we use mutual information and decoding analyses to probe the information content about 3-D reaching and grasping of 7 different LFP frequency bands in the range of 0.3 Hz – 400 Hz. LFPs were recorded via 96-microelectrode arrays in primary motor cortex (M1) of two monkeys performing free reaching to grasp moving objects. Mutual information analyses revealed that higher frequency bands (e.g. 100 – 200 Hz and 200 – 400 Hz) carried the most information about the examined kinematics. Furthermore, Kalman filter decoding revealed that broadband high frequency LFPs, likely reflecting multiunit activity, provided the best decoding performance as well as substantial accuracy in reconstructing reach kinematics, grasp aperture and aperture velocity. These results indicate that LFPs, especially high frequency bands, could be useful signals for neural interfaces controlling 3-D reach and grasp kinematics.