Novel abietane diterpenoids and aromatic compounds from Cladonia rangiferina and their antimicrobial activity against antibiotics resistant bacteria
Novel abietane diterpenoids and aromatic compounds from Cladonia rangiferina and their antimicrobial activity against antibiotics resistant bacteria
复制标题
DOI：
10.1248/cpb.56.89
复制
发表时间：
2008-01-01
影响因子：
1.7
通讯作者：
Hashimoto, Toshihiro
中科院分区：
文献类型：
--
作者：
Yoshikawa, Kazuko;Kokudo, Naoki;Hashimoto, Toshihiro
从兰花枝藻中分离得到两个新的松烷二萜类化合物，分别为双烯醇类化合物A(1)和B(2)。在本研究中，还分离到4个已知的二萜类化合物(3-6)、4个已知的二萜类化合物(7-10)、1个已知的异海松烷二萜类化合物(11)和6个已知的芳香族化合物。这些结构主要通过广泛的核磁共振实验来阐明。Hanagokenol A(1)是一种在糖醇的C-6和C-18之间以醚键连接的松香烷二萜。Hanagokenol B(2)也是一种独特的二萜化合物，具有伽马内酯，该内酯在12-羟基脱氢松油醇的C-6/C-7之间发生裂解和氧化。此外，对分离得到的化合物(1-17)进行了对甲氧西林耐药金黄色葡萄球菌(MRSA)和万古霉素耐药肠球菌(VRE)的抗菌活性测试。
From Cladonia rangiferina were isolated two novel abietane diterpenoids, hanagokenols A (1) and B (2). Also in this investigation, four known abitetane diterpenoids (3 - 6), four known labdane diterpenoids (7 - 10), one known isopimarane diterpenoid (11), and six known aromatic compounds were isolated. These structures were elucidated primarily through extensive NMR experiments. Hanagokenol A (1) was a unique abietane diterpene having an ether linkage between C-6 and C-18 of sugiol. Hanagokenol B (2) is also a unique secoabietane diterpene, having gamma-lactone which occurred by cleavage and subsequently oxidation between C-6/C-7 of 12-hydroxydehydroabietinol. Furthermore, all the isolated compounds (1 - 17) were tested for the antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).