Cathepsin D levels are reduced in patients with preeclampsia in Korean population
Cathepsin D levels are reduced in patients with preeclampsia in Korean population
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DOI：
10.1016/j.clinbiochem.2013.07.022
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发表时间：
2013-12-01
影响因子：
2.8
通讯作者：
Moon, ChongSoo
中科院分区：
文献类型：
--
作者：
Kim, Ho Yeon;Lee, Maria;Moon, ChongSoo
目的：比较先兆子痫和血压正常妊娠的组织蛋白酶 Din 循环水平。设计和方法：本研究纳入了 50 名孕妇和 20 名健康非妊娠患者。 50 名孕妇中，15 名患有先兆子痫，35 名患者血压正常。使用酶联免疫吸附测定 (ELISA) 试剂盒测量可溶性组织蛋白酶 D 的血清水平。结果：先兆子痫患者的组织蛋白酶 D 水平显着低于血压正常的妊娠患者 (p = 0.033)。先兆子痫和非妊娠健康患者的血清组织蛋白酶 D 水平显示出相似的结果。血清组织蛋白酶 D 水平与先兆子痫的严重程度或小于胎龄儿的发生率不呈正相关。 结论：我们得出结论，组织蛋白酶 D 水平降低是导致先兆子痫发病的重要因素，可能是通过抑制正常滋养层细胞的侵袭而实现的。这些结果有助于理解这一严重的产科问题。 (C) 2013 年加拿大临床化学家协会。由爱思唯尔公司出版。保留所有权利。
Objectives: To compare the circulating levels of cathepsin Din preeclamptic and normotensive pregnancies.Design and methods: Fifty pregnant and 20 healthy non-pregnant patients were enrolled in this study. Of the 50 pregnant patients, 15 were preeclamptic and 35 patients were normotensive. Serum levels of soluble cathepsin D were measured with an enzyme-linked immunosorbent assay (ELISA) kit.Results: Cathepsin D levels were significantly lower in preeclamptic patients than normotensive pregnant patients (p = 0.033). The serum levels of cathepsin D in preeclamptic and non-pregnant healthy patients showed similar results. The serum levels of cathepsin D were not positively correlated with preeclampsia severity or the incidence of delivery of small for gestational age infants.Conclusions: We conclude that a reduced cathepsin D level is an important factor that may contribute to the pathogenesis of preeclampsia, possibly by inhibiting normal trophoblastic invasion. These results contribute to the understanding of this serious obstetric problem. (C) 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.