ON THE DIRECT EPOXIDATION OF GLYCALS - APPLICATION OF A REITERATIVE STRATEGY FOR THE SYNTHESIS OF BETA-LINKED OLIGOSACCHARIDES
ON THE DIRECT EPOXIDATION OF GLYCALS - APPLICATION OF A REITERATIVE STRATEGY FOR THE SYNTHESIS OF BETA-LINKED OLIGOSACCHARIDES
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DOI：
10.1021/ja00199a028
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发表时间：
1989-08-16
影响因子：
15
通讯作者：
DANISHEFSKY, SJ
中科院分区：
文献类型：
--
作者：
HALCOMB, RL;DANISHEFSKY, SJ
描述了使用二甲基二环氧乙烷进行糖醛的首次直接环氧化。这种反应的产物1，2-脱水糖被用于β-连接寡糖的立体有择构建。一个关键要素是使用具有非参与保护基团的糖醛以避免并发症。
The use of dimethyldioxirane for the first direct epoxidation of glycals is described. The products of such reactions, 1,2-anhydro sugars, are employed in the stereospecific construction of .beta.-linked oligosaccharides. A key element is the use of glycals with nonparticipating protecting groups to avoid complications.