Surgical implantation and biocompatibility of central nervous system auditory prostheses.
Surgical implantation and biocompatibility of central nervous system auditory prostheses.
复制标题
中枢神经系统听觉假体的手术植入和生物相容性。
DOI：
10.1177/000348948909801209
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Anderson,DJ
中科院分区：
文献类型：
--
作者：
Niparko,JK;Altschuler,RA;Xue,XL;Wiler,JA;Anderson,DJ
As part of a program to determine the feasibility of a CNS auditory prosthesis, the tissue reaction to electrodes chronically implanted in the cochlear nucleus (CN) of the guinea pig was examined. Varied open operative approaches and microelectrode designs were utilized. Silicon substrate thin film and platinum-iridium wire electrodes, tethered and untethered, were placed successfully in different divisions of the CN. Implantation through a posterior suboccipital approach was most successful. Histologic examinations demonstrated a glial cell proliferation confined to the area of the electrode track that never exceeded 15 μm in width. No neuronal loss or significant effect on cell morphology was seen, and reactive cells were absent. Electrode migration was apparent in a minority of animal preparations. Although potential problems were identified, our findings lend support to the feasibility of implanting a neuroprosthesis in the CN and have helped to establish methods for future studies of chronic intranuclear stimulation.
