Neoneurogenesis: Tumors may initiate their own innervation by the release of neurotrophic factors in analogy to lymphangiogenesis and neoangiogenesis
Neoneurogenesis: Tumors may initiate their own innervation by the release of neurotrophic factors in analogy to lymphangiogenesis and neoangiogenesis
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DOI：
10.1016/j.mehy.2006.01.015
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发表时间：
2006-01-01
影响因子：
4.7
通讯作者：
Zaenker, Kurt S.
中科院分区：
文献类型：
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作者：
Entschladen, Frank;Palm, Daniel;Zaenker, Kurt S.
恶性肿瘤经常释放血管生成因子，导致肿瘤血管化，这一过程称为新血管生成。当肿瘤超过一定大小时，这种新血管生成为肿瘤提供足够的营养。最近，一个类似的机制已被假定为新的淋巴管在肿瘤中的发展，称为淋巴管生成。因此，肿瘤可以像任何其他生长或再生组织一样进入循环和淋巴引流。此外，已经假设新血管生成和淋巴管生成支持转移发展。阐述了这个模型，我们在此提出了强有力的论据，新的理论，肿瘤启动自己的神经支配的神经营养因子的释放类似于淋巴管生成和新生血管。对于这个过程，我们创造了术语neoneurogenesis。神经发生可能进一步支持转移的形成，因为向内生长的神经末梢可以释放促进转移发展的神经递质。引人注目的是，肿瘤组织中神经细胞标志物的存在已被证明是癌症疾病过程的预后标志物，我们最近报道了神经递质去甲肾上腺素在小鼠模型中的转移增加功能。(c)2006爱思唯尔有限公司保留所有权利。
Malignant tumors frequently release angiogenic factors, which lead to the vascularization of the tumor, a process called neoangiogenesis. This neoangiogenesis provides sufficient nourishment of the tumor when it exceeds a certain size. Recently, a similar mechanism has been postulated for the development of new lymph vessels in tumors, termed lymphangiogenesis. Thus, tumors get access to the circulation and lymph drainage like any other growing or regenerating tissue. Furthermore, it has been hypothesized that neoangiogenesis and lymphangiogenesis support metastasis development. Elaborating on this model, we herein present strong arguments for the new theory that tumors initiate their own innervation by the release of neurotrophic factors in analogy to lymphangiogenesis and neoangiogenesis. For this process, we coin the term neoneurogenesis. It is likely that neoneurogenesis further supports the formation of metastases, since the ingrown nerve endings can release neurotransmitters which enhance the metastasis development. Strikingly, the presence of nerve cell markers in tumor tissues has been shown to be a prognostic marker for the course of a cancer disease, and we have recently reported on the metastasis-increasing function of the neurotransmitter norepinephrine in a mouse model. (c) 2006 Elsevier Ltd. All rights reserved.