EFFECT OF ANTI-OESTROGEN TAMOXIFEN ON PLASMA-LEVELS OF LUTEINIZING-HORMONE, FOLLICLE-STIMULATING-HORMONE, PROLACTIN, ESTRADIOL AND PROGESTERONE IN NORMAL PREMENOPAUSAL WOMEN
EFFECT OF ANTI-OESTROGEN TAMOXIFEN ON PLASMA-LEVELS OF LUTEINIZING-HORMONE, FOLLICLE-STIMULATING-HORMONE, PROLACTIN, ESTRADIOL AND PROGESTERONE IN NORMAL PREMENOPAUSAL WOMEN
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DOI：
10.1677/joe.0.0700421
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发表时间：
1976-01-01
影响因子：
4
通讯作者：
GRIFFITHS, K
中科院分区：
文献类型：
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作者：
GROOM, GV;GRIFFITHS, K
在6名女性志愿者的2个月经周期中，每天测定血浆LH [促黄体生成素]、FSH [促卵泡激素]、催乳素、雌二醇和孕酮水平。在第1个周期（对照）期间，未给予治疗，观察到这些激素的正常分泌。口服他莫昔芬（20 mg/天），在第二周期的卵泡期持续5或10天，未引起周期总长度或周期中期促性腺激素峰发生时间的变化。在对照和试验周期中，LH、FSH和孕酮的分泌差异不大。在测试周期期间观察到雌二醇水平增加2至8倍，这在周期中期和黄体中期激素峰值时最明显。在周期中期，血浆催乳素水平显著降低，但在周期的剩余时间内未观察到真实的差异。他莫昔芬可直接作用于卵巢，刺激雌二醇释放，而无需促性腺激素刺激。由于即使在高雌二醇水平下，该药也明显抑制催乳素分泌，另一种解释可能是，催乳素浓度降低可通过正常浓度的促性腺激素增强卵巢刺激。[This研究显示了他莫昔芬在乳腺癌治疗中的作用机制。]。
Plasma levels of LH [luteinizing hormone], FSH [follicle-stimulating hormone], prolactin, estradiol and progesterone were determined daily during 2 menstrual cycles in 6 women volunteers. During the 1st (control) cycle no treatment was given and normal secretion of these hormones was observed. Oral administration of tamoxifen (20 mg/day), for 5 or 10 days of the follicular phase of the 2nd cycle, caused no change in the overall length of the cycle or the time of occurrence of the midcycle gonadotropin surge. There was little difference in the secretion of LH, FSH and progesterone during the control and test cycles. A 2- to 8-fold increase in estradiol levels was observed during the test cycle which was most pronounced at the times of midcycle and midluteal hormone peaks. There was a significant decrease in plasma prolactin levels at midcycle, but no real difference could be seen during the remainder of the cycle. Tamoxifen may act directly on the ovary to stimulate estradiol release without intermediary gonadotropin stimulation. As the drug apparently inhibited prolactin secretion even in the presence of high estradiol levels, an alternative explanation may be that the reduced prolactin concentration permits augmented ovarian stimulation by normal concentrations of gonadotropins. [This study shows a mechanism of action for tamoxifen in breast cancer treatment.].