Past and Future Directions for Research on Cellular Senescence.
Past and Future Directions for Research on Cellular Senescence.
复制标题
细胞衰老研究的过去和未来方向。
DOI：
10.1101/cshperspect.a041205
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发表时间：
2024
影响因子：
5.4
通讯作者：
Kirkland,JamesL
中科院分区：
文献类型：
--
作者：
Zhu,Yi;Anastasiadis,ZachariasP;EspindolaNetto,JairMachado;Evans,Tamara;Tchkonia,Tamar;Kirkland,JamesL
细胞衰老最初由 Hayflick 和 Moorehead 在 20 世纪 60 年代初描述。他们注意到在人类原代细胞重复传代培养后细胞周期持续停滞。半个多世纪后，细胞衰老已被公认为衰老的基本支柱之一。开发衰老疗法，即选择性消除或针对衰老细胞的干预措施，已成为健康研究的重点。在本文中，我们指出了细胞衰老研究的主要里程碑，讨论了当前的挑战，并指出了这个快速发展领域的未来方向。
Cellular senescence was initially described in the early 1960s by Hayflick and Moorehead. They noted sustained cell-cycle arrest after repeated subculturing of human primary cells. Over half a century later, cellular senescence has become recognized as one of the fundamental pillars of aging. Developing senotherapeutics, interventions that selectively eliminate or target senescent cells, has emerged as a key focus in health research. In this article, we note major milestones in cellular senescence research, discuss current challenges, and point to future directions for this rapidly growing field.